{"id":53874,"date":"2015-03-14T18:21:51","date_gmt":"2015-03-14T22:21:51","guid":{"rendered":"https:\/\/www.erdheim-chester.org\/%e6%8f%90%e4%ba%a4%e4%bb%98%e6%ac%be%e4%ba%ba%e4%b8%8a%e8%a8%b4\/"},"modified":"2025-05-07T15:50:47","modified_gmt":"2025-05-07T19:50:47","slug":"%e6%8f%90%e4%ba%a4%e4%bb%98%e6%ac%be%e4%ba%ba%e4%b8%8a%e8%a8%b4","status":"publish","type":"page","link":"https:\/\/www.erdheim-chester.org\/zh-hant\/%e6%8f%90%e4%ba%a4%e4%bb%98%e6%ac%be%e4%ba%ba%e4%b8%8a%e8%a8%b4\/","title":{"rendered":"\u63d0\u4ea4\u4ed8\u6b3e\u4eba\u4e0a\u8a34"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/www.erdheim-chester.org\/wp-content\/uploads\/2024\/12\/Untitled-design-96-1.png&#8221; background_position=&#8221;bottom_center&#8221; background_vertical_offset=&#8221;20%&#8221; custom_padding=&#8221;20px||20px||true|false&#8221; global_module=&#8221;28071&#8243; 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title_text_color=&#8221;#FFFFFF&#8221; title_font_size=&#8221;40px&#8221; custom_margin=&#8221;||3px|||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][et_pb_button button_text=&#8221;\u806f\u7e6b\u6211\u5011&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_size=&#8221;15px&#8221; button_text_color=&#8221;#C02E43&#8243; button_bg_color=&#8221;rgba(10,22,64,0.53)&#8221; button_border_width=&#8221;0px&#8221; button_icon=&#8221;&#xe60f;||divi||400&#8243; button_icon_color=&#8221;#C02E43&#8243; button_icon_placement=&#8221;left&#8221; button_on_hover=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; filter_opacity__hover_enabled=&#8221;on|hover&#8221; filter_opacity__hover=&#8221;70%&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row admin_label=&#8221;\u6392&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p>\u5927\u591a\u6578 ECD \u6cbb\u7642\u4ecd\u7136\u88ab\u8996\u70ba\u6a19\u7c64\u5916\u6cbb\u7642\uff0c\u9019\u610f\u5473\u8457\u5728\u7f8e\u570b\uff0c\u901a\u5e38\u9700\u8981\u591a\u6b21\u4e0a\u8a34\u624d\u80fd\u7372\u5f97\u4ed8\u6b3e\u4eba\u7684\u6279\u51c6\u3002ECD\u70ba\u4e86\u6e1b\u8f15\u91ab\u7642\u63d0\u4f9b\u8005\u5de5\u4f5c\u4eba\u54e1\u7684\u8ca0\u64d4\uff0c\u5df2\u7d93\u6536\u96c6\u4e86\u793a\u4f8b\u4e0a\u8a34\u4fe1\u548c\u652f\u63f4\u671f\u520a\u6587\u7ae0\u3002\u4ee5\u4e0b\u8cc7\u8a0a\u5c07\u63d0\u4f9b\u6709\u95dc\u4e0a\u8a34\u6d41\u7a0b\u7684\u6307\u5c0e\uff0c\u4ee5\u4fbf\u70ba\u60a8\u7684 ECD \u60a3\u8005\u5be6\u73fe\u6cbb\u7642\u8986\u84cb\u3002\u5c0d\u65bc\u5c45\u4f4f\u5728\u7f8e\u570b\u4ee5\u5916\u7684\u60a3\u8005\uff0c\u7372\u5f97\u7279\u5b9a\u6cbb\u7642\u6279\u51c6\u7684\u904e\u7a0b\u53ef\u80fd\u6703\u6709\u6240\u4e0d\u540c\u3002\u4f46\u662f\uff0c\u76f8\u540c\u7684\u8cc7\u8a0a\u53ef\u80fd\u4ecd\u7136\u6709\u52a9\u65bc\u7372\u5f97\u7279\u5b9a\u6cbb\u7642\u7684\u6279\u51c6\u3002    <\/p>\n<p>\u6839\u64da\u5177\u9ad4\u60c5\u6cc1\u8207\u4fdd\u96aa\u516c\u53f8\u5408\u4f5c\u9700\u8981\u82b1\u8cbb\u5927\u91cf\u6642\u9593\u548c\u7cbe\u529b\u3002\u7528\u65bc\u6cbb\u7642 Erdheim-Chester \u75c5\u7684\u85e5\u7269\u7576\u7136\u4e5f\u4e0d\u4f8b\u5916\u3002ECD \u7684\u4e00\u4e9b\u8d85\u9069\u61c9\u75c7\u6cbb\u7642\u5305\u62ec\uff1a\u963f\u90a3\u767d\u6eef\u7d20\u3001\u9054\u62c9\u975e\u5c3c\u3001\u66f2\u7f8e\u66ff\u5c3c\u3001\u8003\u6bd4\u66ff\u5c3c\u3001\u514b\u62c9\u5c48\u6ff1\u548c\u7532\u6c28\u8776\u5464\u3002\u5927\u591a\u6578\u4fdd\u96aa\u516c\u53f8\u90fd\u6709\u4e00\u4efd\u9700\u8981\u9810\u5148\u6388\u6b0a\u7684\u85e5\u7269\u6e05\u55ae\uff0c\u9019\u4e9b\u85e5\u7269\u901a\u5e38\u90fd\u5728\u9019\u4e9b\u6e05\u55ae\u4e0a\u3002\u9019\u4e9b\u85e5\u7269\u50f9\u683c\u6602\u8cb4\uff0c\u60a3\u8005\u96e3\u4ee5\u55ae\u7368\u627f\u64d4\u3002    <\/p>\n<p>\u4ed8\u6b3e\u4eba\u4f7f\u7528\u7684\u5178\u578b\u8a55\u4f30\u6d41\u7a0b\u662f\u8b93\u8b77\u58eb\u6216\u85e5\u5291\u5e2b\u5be9\u67e5\u8acb\u6c42\uff0c\u4e26\u67e5\u770b\u8a72\u85e5\u7269\u662f\u5426\u88ab\u8acb\u6c42\u7528\u65bc FDA \u6279\u51c6\u7684\u9069\u61c9\u75c7\u3002\u7576\u85e5\u7269\u672a\u51fa\u73fe\u5728 FDA \u6279\u51c6\u6e05\u55ae\u4e0a\u6642\uff0c\u8a72\u8acb\u6c42\u5c07\u81ea\u52d5\u88ab\u62d2\u7d55\u3002\u9019\u6703\u4f7f\u8acb\u6c42\u9032\u5165\u4e0a\u8a34\u968e\u6bb5\uff0c\u901a\u5e38\u6703\u4ea4\u7d66\u91ab\u7642\u4e3b\u4efb\u9032\u884c\u9032\u4e00\u6b65\u8a55\u4f30\u3002\u6b64\u968e\u6bb5\u5b58\u5728\u5f88\u5927\u7684\u53ef\u8b8a\u6027\uff0c\u4f46\u6b64\u6642\u7684\u8acb\u6c42\u901a\u5e38\u4e5f\u6703\u88ab\u62d2\u7d55\u3002\u5982\u679c\u85e5\u7269\u6700\u7d42\u7372\u5f97\u6279\u51c6\uff0c\u6709\u6642\u6700\u591a\u9700\u8981\u56db\u6b21\u4e0a\u8a34\u3002\u7576\u6240\u6709\u5167\u90e8\u4e0a\u8a34\u90fd\u7528\u76e1\u6642\uff0c\u60a3\u8005\u6709\u6b0a\u8981\u6c42\u5916\u90e8\u5be9\u67e5\u3002\u9019\u500b\u904e\u7a0b\u901a\u5e38\u6703\u7d66\u60a3\u8005\u5e36\u4f86\u58d3\u529b\uff0c\u800c\u91ab\u751f\u548c\u5de5\u4f5c\u4eba\u54e1\u6703\u5f88\u8017\u6642\u3002      <\/p>\n<p>\u70ba\u4e86\u652f\u6301\u9019\u4e9b\u52aa\u529b\uff0c\u5df2\u7d93\u70ba\u7d93\u5e38\u958b\u5177\u548c\u62d2\u7d55\u627f\u4fdd\u7684\u85e5\u7269\u5275\u5efa\u4e86\u4e00\u7cfb\u5217\u6587\u7ae0\u548c\u4e00\u5c01\u4e0a\u8a34\u4fe1\u3002\u4ee5\u4e0b\u85e5\u7269\u6587\u7ae0\u548c\u4e0a\u8a34\u4fe1\u7684\u9023\u7d50\u5df2\u5275\u5efa\uff0c\u4ee5\u8aac\u660e\u91ab\u52d9\u4eba\u54e1\u7372\u5f97\u60a3\u8005\u4fdd\u96aa\u516c\u53f8\u7684\u6cbb\u7642\u6279\u51c6\u3002\u5176\u4ed6\u91ab\u751f\u5df2\u7d93\u6210\u529f\u5730\u5728\u7533\u8acb\u4e2d\u4f7f\u7528\u4e86\u9019\u4e9b\u8868\u683c\u3002\u9019\u4e9b\u4fe1\u4ef6\u4f5c\u70ba\u7bc4\u672c\u6307\u5357\uff0c\u4ee5\u65b9\u4fbf\u4e0a\u8a34\uff0c\u800c\u6587\u7ae0\u5247\u4ee5\u91ab\u5b78\u4e8b\u5be6\u548c\u7d50\u679c\u652f\u63f4\u8acb\u6c42\u3002   <\/p>\n<p><strong>\u91cd\u8981\u63d0\u793a<\/strong> \u2013 \u5efa\u8b70\u91ab\u751f\u548c\u5de5\u4f5c\u4eba\u54e1\u4f7f\u7528\u4ee3\u78bc ICD-10 D76.3\uff0c\u5373\u201c\u5176\u4ed6\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7\u7d9c\u5408\u5f81\u201d\u548c\/\u6216 C96A\u201c\u7d44\u7e54\u7d30\u80de\u8089\u7624\u201d\u9032\u884c\u67d0\u4e9b\u5f71\u50cf\u5b78\u7814\u7a76\uff08\u5c24\u5176\u662f PET \u6383\u63cf\uff09\uff0c\u7528\u65bc ECD \u6cbb\u7642\u548c\u76e3\u6e2c\u3002<\/p>\n<p>\u5982\u679c\u60a8\u5728\u6b64\u904e\u7a0b\u4e2d\u9700\u8981\u66f4\u591a\u8aac\u660e\u6216\u60f3\u8981\u63d0\u4f9b\u53cd\u994b\uff0c\u8acb\u806f\u7e6b ECDGA\u3002<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<\/p>\n\n<table id=\"tablepress-5\" class=\"tablepress tablepress-id-5\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Treatment<\/th><th class=\"column-2\">Example Appeal Letter<\/th><th class=\"column-3\">Supporting peer-reviewed article links\u00a0(listed according to involvement)<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">Anakinra (Kineret)<\/td><td class=\"column-2\"><a href=\"https:\/\/www.erdheim-chester.org\/wp-content\/uploads\/2019\/10\/Letter-Requesting-Anakinra.docx\" target=\"_blank\">Letter Requesting Anakinra Treatment<\/a><\/td><td class=\"column-3\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Rationale+and+efficacy+of+interleukin-1+targeting+in+Erdheim%E2%80%93Chester+disease\" target=\"_blank\">Bone<\/a><br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Erdheim%E2%80%93Chester+disease+with+cardiac+involvement+successfully+treated+with+anakinra\" target=\"_blank\">Cardiac<\/a><br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Successful+treatment+of+Erdheim%E2%80%93Chester+disease+with+combination+of+interleukin-1-targeting+drugs+and+high-dose+glucocorticoids\" target=\"_blank\">CNS<\/a><br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Treatment+of+pediatric+Erdheim-Chester+disease+with+interleukin-1%E2%80%93targeting+drugs\" target=\"_blank\">Pediatric<\/a><br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Favorable+radiological+outcome+of+skeletal+erdheim-chester+disease+involvement+with+anakinra\" target=\"_blank\">Skeletal<\/a><\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">Cladribine (Leustatin, Litak or Movectro)<\/td><td class=\"column-2\"><a href=\"https:\/\/www.erdheim-chester.org\/wp-content\/uploads\/2019\/10\/Letter-Requesting-Cladribine.docx\" target=\"_blank\">Letter Requesting Cladribine Treatment<\/a><\/td><td class=\"column-3\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=24011030\" target=\"_blank\">Comprehensive Review<\/a><br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Clinical+considerations+and+key+issues+in+the+management+of+patients+with+Erdheim-Chester+Disease%3A+a+seven+case+series\" target=\"_blank\">Multiple Systems<\/a><br \/>\n<a href=\"http:\/\/bjo.bmj.com\/content\/88\/6\/832.full\" target=\"_blank\">Ocular<\/a><\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">Methotrexate (Trexall or Rheumatrex)<\/td><td class=\"column-2\"><a href=\"https:\/\/www.erdheim-chester.org\/wp-content\/uploads\/2019\/10\/Letter-Requesting-Methotrexate.docx\" target=\"_blank\">Letter Requesting Methotrexate Treatment<\/a><\/td><td class=\"column-3\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=24362833\" target=\"_blank\">Cardiac<\/a><br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=A+role+for+methotrexate+in+the+management+of+non-infectious+orbital+inflammatory+disease\" target=\"_blank\">Ocular<\/a><\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">Cobimetinib (Cotellic)<\/td><td class=\"column-2\"><a href=\"https:\/\/www.erdheim-chester.org\/wp-content\/uploads\/2015\/03\/Letter-Requesting-Coverage-of-Cobimetinib.docx\" target=\"_blank\">Letter Requesting Cobimetinib Treatment<\/a><\/td><td class=\"column-3\"><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.14284\/abstract;jsessionid=8D21486CF8F795BFE6D019B086E24375.f02t03\" target=\"_blank\">Efficacy of Cobimetinib<\/a><br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1012-y\" target=\"_blank\">Efficacy of MEK Inhibition<\/a><\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">Trametinib (Mekinist) and\/or Dabrafenib (Tafinlar)<\/td><td class=\"column-2\"><a href=\"https:\/\/www.erdheim-chester.org\/wp-content\/uploads\/2015\/03\/Letter-Requesting-Coverage-of-Trametinib.docx\" target=\"_blank\">Letter Requesting Trametinib Treatment<\/a><br \/>\n<br \/>\n<a href=\"https:\/\/www.erdheim-chester.org\/wp-content\/uploads\/2015\/03\/Letter-Requesting-Coverage-of-Dabrafenib.docx\" target=\"_blank\">Letter Requesting Dabrafenib Treatment<\/a><\/td><td class=\"column-3\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5291734\/\" target=\"_blank\">Efficacy of Trametinib or Dabrafenib<\/a><br \/>\n<a href=\"http:\/\/www.bloodjournal.org\/content\/129\/7\/879.long?sso-checked=true\" target=\"_blank\">Combined Dabrafenib and Trametinib Treatment<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n<p>[\/et_pb_text][et_pb_button button_text=&#8221;\u806f\u7e6b\u6211\u5011&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; button_url=&#8221;https:\/\/www.erdheim-chester.org\/zh-hant\/%e8%81%af%e7%b9%ab%e6%88%91%e5%80%91\/&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_dmb_breadcrumbs _builde 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