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_builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_padding=&#8221;0px||||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>ECD \u6703\u5c0e\u81f4\u54ea\u4e9b\u554f\u984c\uff1f<\/h3>\n<p>ECD \u5e7e\u4e4e\u53ef\u4ee5\u5f71\u97ff\u8eab\u9ad4\u7684\u5404\u500b\u90e8\u4f4d\uff0c\u5305\u62ec\u817f\u90e8\u548c\u624b\u81c2\u7684\u9577\u9aa8\u3001\u76ae\u819a\u3001\u773c\u5f8c\u7d44\u7e54\u3001\u80ba\u3001\u5927\u8166\u3001\u5782\u9ad4\u3001\u814e\u81df\u548c\u8f38\u5c3f\u7ba1\u5468\u570d\u7684\u7d44\u7e54\u3001\u8179\u8154\u3001\u5fc3\u81df\u3001\u8840\u7ba1\u3001\u814e\u4e0a\u817a\uff0c\u4ee5\u53ca\u66f4\u7f55\u898b\u7684\u5176\u4ed6\u5668\u5b98\u3002\u6240\u6d89\u53ca\u7684\u5177\u9ad4\u5668\u5b98\u53ef\u80fd\u6703\u6709\u6240\u4e0d\u540c;\u7136\u800c\uff0c\u5728\u8d85\u904e90%\u7684 ECD \u60a3\u8005\u4e2d\uff0c\u6700\u5e38\u898b\u7684\u8868\u73fe\u662f\u819d\u95dc\u7bc0\u5468\u570d\u7684\u817f\u9aa8\u53d7\u7d2f\u3002\u53d7\u7d2f\u5668\u5b98\u7684\u6578\u91cf\u53ef\u80fd\u56e0\u4eba\u800c\u7570\uff0c\u56e0\u6b64\u60a3\u8005\u4e4b\u9593\u7684\u81e8\u5e8a\u8868\u73fe\u548c\u4fb5\u8972\u6027\u5dee\u7570\u5f88\u5927\u3002  <\/p>\n<h3>\u7c21\u53f2<\/h3>\n<p>\u81ea 1930 \u5e74\u5967\u5730\u5229\u75c5\u7406\u5b78\u5bb6 Jakob Erdheim \u548c\u7f8e\u570b\u75c5\u7406\u5b78\u5bb6 William Chester \u9996\u6b21\u63cf\u8ff0 ECD \u4ee5\u4f86\uff0c\u4e16\u754c\u4e0a\u5df2\u767c\u8868\u7684 ECD \u75c5\u4f8b\u6578\u91cf\u975e\u5e38\u6709\u9650\u3002\u7531\u65bc ECD \u975e\u5e38\u7f55\u898b\uff0c\u4e26\u4e14\u5728\u5e38\u898b\u7684\u91ab\u5b78\u6559\u79d1\u66f8\u4e2d\u6c92\u6709\u8a0e\u8ad6\uff0c\u56e0\u6b64\u8a31\u591a\u91ab\u751f\u5f9e\u672a\u807d\u8aaa\u904e\u5b83\u3002\u5b83\u4e5f\u88ab\u8a8d\u70ba\u96e3\u4ee5\u8a3a\u65b7\u3002\u7531\u65bc\u9019\u4e9b\u539f\u56e0\uff0c\u5927\u591a\u6578\u4eba\u8a8d\u70ba\u9019\u7a2e\u75be\u75c5\u88ab\u4f4e\u4f30\u4e86\u3002\u7136\u800c\uff0c\u8fd1\u5e74\u4f86\uff0c\u96a8\u8457\u610f\u8b58\u7684\u63d0\u9ad8\uff0c\u8a3a\u65b7\u7684\u6578\u91cf\u4f3c\u4e4e\u8d8a\u4f86\u8d8a\u591a\u3002\u6b64\u5916\uff0c\u96a8\u8457 MAPK \u901a\u8def\u7a81\u8b8a\u7684\u767c\u73fe\uff0c\u6cbb\u7642\u5f97\u5230\u4e86\u986f\u8457\u6539\u5584\uff0c\u5c0e\u81f4\u7f8e\u570b FDA \u6279\u51c6\u4e86\u5169\u7a2e\u9776\u5411\u85e5\u7269 vemurafenib \u548c cobimetinib \u7528\u65bc ECD \u60a3\u8005\u3002     <\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_3,1_3&#8243; 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