{"id":42584,"date":"2011-01-23T10:15:51","date_gmt":"2011-01-23T16:15:51","guid":{"rendered":"https:\/\/www.erdheim-chester.org\/?p=42584"},"modified":"2026-10-12T10:04:46","modified_gmt":"2026-10-12T15:04:46","slug":"prijs-2011","status":"publish","type":"post","link":"https:\/\/www.erdheim-chester.org\/nl\/2011-award\/","title":{"rendered":"Hypoxie en ontsteking in de micro-omgeving van de ziekte van Erdheim-Chester: inzichten in de pathogenese en implicaties voor een behandelingsvoorstel"},"content":{"rendered":"<h3>[et_pb_section global_module=\"175201\"][\/et_pb_section]<\/h3>\n<h4><strong>Year Awarded:<\/strong> 2011<br \/>\n<strong>Amount: <\/strong>49,745 USD<\/h4>\n<p>In April 2010, only one month after receiving a 501(c)(3) designation, the organization announced it would be awarding a $50,000 ECD research grant and put out a Request for Proposals (RFP) to the international medical research community.\u00a0 In November 2010, the first grant recipient was chosen.<\/p>\n<p>The ECD Global Alliance 2010 grant was awarded to Lorenzo Dagna, MD at San Raffaele Scientific Institute in Milano, Italy for the study described as, \u201c<a href=\"https:\/\/www.erdheim-chester.org\/DataFiles\/PresentationsAndArticles\/Dagna_2010_Study_Abstract.pdf\" target=\"_blank\" rel=\"noopener\">Hypoxia and inflammation in Erdheim-Chester disease microenvironment: insights on the pathogenesis and implications for therapy proposal\u201d<\/a>. The aim of this study was to better define the microenvironment inside ECD lesions and to evaluate the possibility of using specific drugs, already available for human usage, to find new therapeutic options for the disease.\u202f The study ran from January 2011 until June 2012.\u202f The results of this study can be found in the Journal of Clinical Oncology, Vol. 310, 2012, in an article entitled, \u201c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22869874\/\" target=\"_blank\" rel=\"noopener\" aria-label=\"Tumor Necrosis Factor as a Master Regulator of Inflammation in Erdheim-Chester Disease: Rationale for the Treatment of Patients with Infliximab - opens in new tab - opens in new tab\">Tumor Necrosis Factor as a Master Regulator of Inflammation in Erdheim-Chester Disease: Rationale for the Treatment of Patients with Infliximab<\/a>.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ECD Global Alliance kent een onderzoekssubsidie van $49.745 toe aan Lorenzo Dagna van het San Raffaele Scientific Institute in Milaan, Itali\u00eb. In het onderzoek werd de micro-omgeving van ECD-laesies bestudeerd, waarbij Tumor Necrosis Factor als een belangrijke regulator van ontstekingen aan het licht kwam en mogelijke therapeutische opties werden onderzocht.<\/p>","protected":false},"author":20,"featured_media":92321,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","cybocfi_hide_featured_image":"","wds_primary_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[306],"tags":[325],"class_list":["post-42584","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-past-awards","tag-325"],"_links":{"self":[{"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/posts\/42584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/comments?post=42584"}],"version-history":[{"count":1,"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/posts\/42584\/revisions"}],"predecessor-version":[{"id":175204,"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/posts\/42584\/revisions\/175204"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/media\/92321"}],"wp:attachment":[{"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/media?parent=42584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/categories?post=42584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/nl\/wp-json\/wp\/v2\/tags?post=42584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}