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\u092c\u0940\u092e\u093e \u0915\u0902\u092a\u0928\u093f\u092f\u094b\u0902 \u0915\u0947 \u0938\u093e\u0925 \u0915\u0947\u0938-\u0926\u0930-\u0915\u0947\u0938 \u0906\u0927\u093e\u0930 \u092a\u0930 \u0915\u093e\u092e \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u092c\u0939\u0941\u0924 \u0938\u092e\u092f \u0914\u0930 \u092a\u094d\u0930\u092f\u093e\u0938 \u0915\u0940 \u0906\u0935\u0936\u094d\u092f\u0915\u0924\u093e \u0939\u094b\u0924\u0940 \u0939\u0948\u0964 Erdheim-Chester \u0930\u094b\u0917 \u0915\u0947 \u0907\u0932\u093e\u091c \u0915\u0947 \u0932\u093f\u090f \u0907\u0938\u094d\u0924\u0947\u092e\u093e\u0932 \u0915\u0940 \u091c\u093e\u0928\u0947 \u0935\u093e\u0932\u0940 \u0926\u0935\u093e\u090f\u0901 \u0928\u093f\u0936\u094d\u091a\u093f\u0924 \u0930\u0942\u092a \u0938\u0947 \u0905\u092a\u0935\u093e\u0926 \u0928\u0939\u0940\u0902 \u0939\u0948\u0902\u0964 ECD \u0915\u0947 \u0932\u093f\u090f \u0915\u0941\u091b \u0911\u092b-\u0932\u0947\u092c\u0932 \u0909\u092a\u091a\u093e\u0930\u094b\u0902 \u092e\u0947\u0902 \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0902: \u090f\u0928\u093e\u0915\u093f\u0928\u0930\u093e, \u0921\u0948\u092c\u094d\u0930\u093e\u092b\u0947\u0928\u093f\u092c, \u091f\u094d\u0930\u0948\u092e\u0947\u091f\u093f\u0928\u093f\u092c, \u0915\u094b\u092c\u0940\u092e\u0947\u091f\u093f\u0928\u093f\u092c, \u0915\u094d\u0932\u0948\u0921\u094d\u0930\u093f\u092c\u093e\u0907\u0928 \u0914\u0930 \u092e\u0947\u0925\u094b\u091f\u094d\u0930\u0947\u0915\u094d\u0938\u0947\u091f\u0964 \u0905\u0927\u093f\u0915\u093e\u0902\u0936 \u092c\u0940\u092e\u093e \u0915\u0902\u092a\u0928\u093f\u092f\u094b\u0902 \u0915\u0947 \u092a\u093e\u0938 \u0926\u0935\u093e\u0913\u0902 \u0915\u0940 \u090f\u0915 \u0938\u0942\u091a\u0940 \u0939\u094b\u0924\u0940 \u0939\u0948 \u091c\u093f\u0938\u0915\u0947 \u0932\u093f\u090f \u092a\u0942\u0930\u094d\u0935-\u0905\u0928\u0941\u092e\u094b\u0926\u0928 \u0915\u0940 \u0906\u0935\u0936\u094d\u092f\u0915\u0924\u093e \u0939\u094b\u0924\u0940 \u0939\u0948, \u0914\u0930 \u092f\u0947 \u0926\u0935\u093e\u090f\u0901 \u0906\u092e\u0924\u094c\u0930 \u092a\u0930 \u0907\u0928 \u0938\u0942\u091a\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0939\u094b\u0924\u0940 \u0939\u0948\u0902\u0964 \u092f\u0947 \u0926\u0935\u093e\u090f\u0901 \u092e\u0939\u0902\u0917\u0940 \u0939\u094b\u0924\u0940 \u0939\u0948\u0902 \u0914\u0930 \u090f\u0915 \u092e\u0930\u0940\u091c \u0915\u0947 \u0932\u093f\u090f \u0905\u0915\u0947\u0932\u0947 \u0907\u0928\u0915\u093e \u0916\u0930\u094d\u091a \u0909\u0920\u093e\u0928\u093e \u092e\u0941\u0936\u094d\u0915\u093f\u0932 \u0939\u094b\u0924\u093e \u0939\u0948\u0964 <\/p>\n

\u092d\u0941\u0917\u0924\u093e\u0928\u0915\u0930\u094d\u0924\u093e \u0926\u094d\u0935\u093e\u0930\u093e \u0909\u092a\u092f\u094b\u0917 \u0915\u0940 \u091c\u093e\u0928\u0947 \u0935\u093e\u0932\u0940 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e \u092e\u0947\u0902 \u0928\u0930\u094d\u0938 \u092f\u093e \u092b\u093e\u0930\u094d\u092e\u093e\u0938\u093f\u0938\u094d\u091f \u0926\u094d\u0935\u093e\u0930\u093e \u0905\u0928\u0941\u0930\u094b\u0927 \u0915\u0940 \u0938\u092e\u0940\u0915\u094d\u0937\u093e \u0915\u0930\u0928\u093e \u0914\u0930 \u092f\u0939 \u0926\u0947\u0916\u0928\u093e \u0936\u093e\u092e\u093f\u0932 \u0939\u0948 \u0915\u093f \u0915\u094d\u092f\u093e \u0926\u0935\u093e \u0915\u094b FDA \u0926\u094d\u0935\u093e\u0930\u093e \u0905\u0928\u0941\u092e\u094b\u0926\u093f\u0924 \u0938\u0902\u0915\u0947\u0924 \u0915\u0947 \u0932\u093f\u090f \u0905\u0928\u0941\u0930\u094b\u0927 \u0915\u093f\u092f\u093e \u091c\u093e \u0930\u0939\u093e \u0939\u0948\u0964 \u091c\u092c \u0926\u0935\u093e FDA \u0926\u094d\u0935\u093e\u0930\u093e \u0905\u0928\u0941\u092e\u094b\u0926\u093f\u0924 \u0938\u0942\u091a\u0940 \u092e\u0947\u0902 \u0926\u093f\u0916\u093e\u0908 \u0926\u0947\u0928\u0947 \u092e\u0947\u0902 \u0935\u093f\u092b\u0932 \u0930\u0939\u0924\u0940 \u0939\u0948, \u0924\u094b \u0905\u0928\u0941\u0930\u094b\u0927 \u0938\u094d\u0935\u091a\u093e\u0932\u093f\u0924 \u0930\u0942\u092a \u0938\u0947 \u0905\u0938\u094d\u0935\u0940\u0915\u093e\u0930 \u0915\u0930 \u0926\u093f\u092f\u093e \u091c\u093e\u0924\u093e \u0939\u0948\u0964 \u092f\u0939 \u0905\u0928\u0941\u0930\u094b\u0927 \u0915\u094b \u0905\u092a\u0940\u0932 \u091a\u0930\u0923 \u092e\u0947\u0902 \u0921\u093e\u0932 \u0926\u0947\u0924\u093e \u0939\u0948, \u091c\u094b \u0906\u092e\u0924\u094c\u0930 \u092a\u0930 \u0906\u0917\u0947 \u0915\u0947 \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u0947 \u0932\u093f\u090f \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0928\u093f\u0926\u0947\u0936\u0915 \u0915\u0947 \u092a\u093e\u0938 \u091c\u093e\u0924\u093e \u0939\u0948\u0964 \u0907\u0938 \u091a\u0930\u0923 \u092e\u0947\u0902 \u092c\u0939\u0941\u0924 \u0905\u0927\u093f\u0915 \u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u0936\u0940\u0932\u0924\u093e \u0939\u094b\u0924\u0940 \u0939\u0948, \u0932\u0947\u0915\u093f\u0928 \u0907\u0938 \u092c\u093f\u0902\u0926\u0941 \u092a\u0930 \u0905\u0928\u0941\u0930\u094b\u0927 \u0915\u094b \u0906\u092e\u0924\u094c\u0930 \u092a\u0930 \u0905\u0938\u094d\u0935\u0940\u0915\u093e\u0930 \u092d\u0940 \u0915\u0930 \u0926\u093f\u092f\u093e \u091c\u093e\u0924\u093e \u0939\u0948\u0964 \u092f\u0926\u093f \u0926\u0935\u093e \u0915\u094b \u0905\u0902\u0924\u0924\u0903 \u092e\u0902\u091c\u0942\u0930\u0940 \u092e\u093f\u0932 \u091c\u093e\u0924\u0940 \u0939\u0948, \u0924\u094b \u0915\u092d\u0940-\u0915\u092d\u0940 \u091a\u093e\u0930 \u0905\u092a\u0940\u0932 \u0924\u0915 \u0915\u0940 \u0906\u0935\u0936\u094d\u092f\u0915\u0924\u093e \u0939\u094b\u0924\u0940 \u0939\u0948\u0964 \u091c\u092c \u0938\u092d\u0940 \u0906\u0902\u0924\u0930\u093f\u0915 \u0905\u092a\u0940\u0932 \u0938\u092e\u093e\u092a\u094d\u0924 \u0939\u094b \u091c\u093e\u0924\u0940 \u0939\u0948\u0902, \u0924\u094b \u0930\u094b\u0917\u0940 \u0915\u094b \u092c\u093e\u0939\u0930\u0940 \u0938\u092e\u0940\u0915\u094d\u0937\u093e \u0915\u0947 \u0932\u093f\u090f \u092a\u0942\u091b\u0928\u0947 \u0915\u093e \u0905\u0927\u093f\u0915\u093e\u0930 \u0939\u094b\u0924\u093e \u0939\u0948\u0964 \u092f\u0939 \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e \u0905\u0915\u094d\u0938\u0930 \u0930\u094b\u0917\u0940 \u0915\u0947 \u0932\u093f\u090f \u0924\u0928\u093e\u0935\u092a\u0942\u0930\u094d\u0923 \u0939\u094b\u0924\u0940 \u0939\u0948 \u0914\u0930 \u0921\u0949\u0915\u094d\u091f\u0930\u094b\u0902 \u0914\u0930 \u0915\u0930\u094d\u092e\u091a\u093e\u0930\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0938\u092e\u092f \u0932\u0947\u0928\u0947 \u0935\u093e\u0932\u0940 \u0939\u094b\u0924\u0940 \u0939\u0948\u0964 <\/p>\n

\u0907\u0928 \u092a\u094d\u0930\u092f\u093e\u0938\u094b\u0902 \u0915\u0947 \u0938\u092e\u0930\u094d\u0925\u0928 \u092e\u0947\u0902, \u0905\u0915\u094d\u0938\u0930 \u0928\u093f\u0930\u094d\u0927\u093e\u0930\u093f\u0924 \u0914\u0930 \u0905\u0938\u094d\u0935\u0940\u0915\u0943\u0924 \u0926\u0935\u093e\u0913\u0902 \u0915\u0947 \u0932\u093f\u090f \u0932\u0947\u0916\u094b\u0902 \u0915\u093e \u090f\u0915 \u0938\u0902\u0917\u094d\u0930\u0939 \u0914\u0930 \u0905\u092a\u0940\u0932 \u092a\u0924\u094d\u0930 \u092c\u0928\u093e\u092f\u093e \u0917\u092f\u093e \u0939\u0948\u0964 \u0930\u094b\u0917\u0940 \u0915\u0947 \u092c\u0940\u092e\u093e \u0935\u093e\u0939\u0915 \u0938\u0947 \u0909\u092a\u091a\u093e\u0930 \u0905\u0928\u0941\u092e\u094b\u0926\u0928 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u0915\u0930\u0928\u0947 \u092e\u0947\u0902 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0915\u0930\u094d\u092e\u091a\u093e\u0930\u093f\u092f\u094b\u0902 \u0915\u0940 \u0938\u0939\u093e\u092f\u0924\u093e \u0915\u0947 \u0932\u093f\u090f \u0926\u0935\u093e \u0932\u0947\u0916\u094b\u0902 \u0914\u0930 \u0905\u092a\u0940\u0932 \u092a\u0924\u094d\u0930\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0928\u093f\u092e\u094d\u0928\u0932\u093f\u0916\u093f\u0924 \u0932\u093f\u0902\u0915 \u092c\u0928\u093e\u090f \u0917\u090f \u0939\u0948\u0902\u0964 \u0905\u0928\u094d\u092f \u0921\u0949\u0915\u094d\u091f\u0930 \u0906\u0935\u0947\u0926\u0928 \u092e\u0947\u0902 \u0907\u0928 \u092b\u093c\u0949\u0930\u094d\u092e \u0915\u093e \u0909\u092a\u092f\u094b\u0917 \u0915\u0930\u0915\u0947 \u0938\u092b\u0932 \u0930\u0939\u0947 \u0939\u0948\u0902\u0964 \u092a\u0924\u094d\u0930 \u0905\u092a\u0940\u0932 \u0915\u0940 \u0938\u0941\u0935\u093f\u0927\u093e \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u091f\u0947\u092e\u094d\u092a\u0932\u0947\u091f \u0917\u093e\u0907\u0921 \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u0915\u093e\u0930\u094d\u092f \u0915\u0930\u0924\u0947 \u0939\u0948\u0902, \u091c\u092c\u0915\u093f \u0932\u0947\u0916 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0924\u0925\u094d\u092f\u094b\u0902 \u0914\u0930 \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937\u094b\u0902 \u0915\u0947 \u0938\u093e\u0925 \u0905\u0928\u0941\u0930\u094b\u0927 \u0915\u093e \u0938\u092e\u0930\u094d\u0925\u0928 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902\u0964 <\/p>\n

\u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923<\/strong> – \u0921\u0949\u0915\u094d\u091f\u0930\u094b\u0902 \u0914\u0930 \u0915\u0930\u094d\u092e\u091a\u093e\u0930\u093f\u092f\u094b\u0902 \u0915\u094b ECD \u0909\u092a\u091a\u093e\u0930 \u0914\u0930 \u0928\u093f\u0917\u0930\u093e\u0928\u0940 \u0915\u0947 \u0905\u0928\u0941\u092a\u094d\u0930\u092f\u094b\u0917\u094b\u0902 \u092e\u0947\u0902 \u0915\u0941\u091b \u0907\u092e\u0947\u091c\u093f\u0902\u0917 \u0905\u0927\u094d\u092f\u092f\u0928\u094b\u0902 (\u0935\u093f\u0936\u0947\u0937 \u0930\u0942\u092a \u0938\u0947 \u092a\u0940\u0908\u091f\u0940 \u0938\u094d\u0915\u0948\u0928) \u0915\u0947 \u0932\u093f\u090f \u0915\u094b\u0921 ICD-10 D76.3 \u091c\u094b “\u0905\u0928\u094d\u092f \u0939\u093f\u0938\u094d\u091f\u093f\u092f\u094b\u0938\u093e\u0907\u091f\u094b\u0938\u093f\u0938 \u0938\u093f\u0902\u0921\u094d\u0930\u094b\u092e” \u0914\u0930\/\u092f\u093e C96A “\u0939\u093f\u0938\u094d\u091f\u093f\u092f\u094b\u0938\u093e\u0907\u091f\u093f\u0915 \u0938\u093e\u0930\u0915\u094b\u092e\u093e” \u0915\u093e \u0909\u092a\u092f\u094b\u0917 \u0915\u0930\u0928\u0947 \u0915\u0940 \u0938\u0932\u093e\u0939 \u0926\u0940 \u091c\u093e\u0924\u0940 \u0939\u0948\u0964<\/p>\n

\u092f\u0926\u093f \u0906\u092a\u0915\u094b \u0907\u0938 \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e \u092e\u0947\u0902 \u0905\u0927\u093f\u0915 \u0938\u0939\u093e\u092f\u0924\u093e \u0915\u0940 \u0906\u0935\u0936\u094d\u092f\u0915\u0924\u093e \u0939\u094b \u092f\u093e \u0906\u092a \u092b\u0940\u0921\u092c\u0948\u0915 \u0926\u0947\u0928\u093e \u091a\u093e\u0939\u0947\u0902, \u0924\u094b \u0915\u0943\u092a\u092f\u093e ECDGA \u0938\u0902\u092a\u0930\u094d\u0915 \u0915\u0930\u0947\u0902\u0964<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t
Treatment<\/th>Example Appeal Letter<\/th>Supporting peer-reviewed article links\u00a0(listed according to involvement)<\/th>\n<\/tr>\n<\/thead>\n
Anakinra (Kineret)<\/td>Letter Requesting Anakinra Treatment<\/a><\/td>Bone<\/a>
\nCardiac<\/a>
\nCNS<\/a>
\nPediatric<\/a>
\nSkeletal<\/a><\/td>\n<\/tr>\n
Cladribine (Leustatin, Litak or Movectro)<\/td>Letter Requesting Cladribine Treatment<\/a><\/td>Comprehensive Review<\/a>
\nMultiple Systems<\/a>
\nOcular<\/a><\/td>\n<\/tr>\n
Methotrexate (Trexall or Rheumatrex)<\/td>Letter Requesting Methotrexate Treatment<\/a><\/td>Cardiac<\/a>
\nOcular<\/a><\/td>\n<\/tr>\n
Cobimetinib (Cotellic)<\/td>Letter Requesting Cobimetinib Treatment<\/a><\/td>Efficacy of Cobimetinib<\/a>
\nEfficacy of MEK Inhibition<\/a><\/td>\n<\/tr>\n
Trametinib (Mekinist) and\/or Dabrafenib (Tafinlar)<\/td>Letter Requesting Trametinib Treatment<\/a>
\n
\nLetter Requesting Dabrafenib Treatment<\/a><\/td>		Efficacy of Trametinib or Dabrafenib<\/a>
\nCombined Dabrafenib and Trametinib Treatment<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n

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