{"id":102050,"date":"2016-04-01T18:13:58","date_gmt":"2016-04-01T23:13:58","guid":{"rendered":"https:\/\/www.erdheim-chester.org\/?p=102050"},"modified":"2026-07-10T12:02:53","modified_gmt":"2026-07-10T17:02:53","slug":"4th-annual-ecd-medical-symposium-paris-france","status":"publish","type":"post","link":"https:\/\/www.erdheim-chester.org\/es\/4th-annual-ecd-medical-symposium-paris-france\/","title":{"rendered":"4th Annual ECD Medical Symposium Paris, France"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”20px||0px||false|false” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.27.6″ _module_preset=”default” width=”65%” width_tablet=”80%” width_phone=”80%” width_last_edited=”on|phone” custom_padding=”||10px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_heading title=”4th Annual ECD Medical Symposium Paris, France” _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row module_class=”single-line-buttons ” _builder_version=”4.27.6″ _module_preset=”default” width=”65%” width_tablet=”80%” width_phone=”80%” width_last_edited=”on|phone” custom_padding=”0px||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_button button_text=”Julien Haroche, MD, PhD” _builder_version=”4.27.7″ _module_preset=”default” custom_button=”on” button_text_size=”16px” button_text_color=”#000000″ button_bg_color=”RGBA(255,255,255,0)” button_border_radius=”0px” button_icon=”||fa||400″ button_icon_color=”#35A4BB” button_icon_placement=”left” button_on_hover=”off” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_button][et_pb_button button_text=”Boulevard de l’H\u00f4pita” _builder_version=”4.27.6″ _module_preset=”default” custom_button=”on” button_text_size=”16px” button_text_color=”#000000″ button_bg_color=”RGBA(255,255,255,0)” button_border_radius=”0px” button_icon=”||fa||900″ button_icon_color=”#35A4BB” button_icon_placement=”left” button_on_hover=”off” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_button][et_pb_button button_text=”Paris, France” _builder_version=”4.27.6″ _module_preset=”default” custom_button=”on” button_text_size=”16px” button_text_color=”#000000″ button_bg_color=”RGBA(255,255,255,0)” button_border_radius=”0px” button_icon=”||divi||400″ button_icon_color=”#35A4BB” button_icon_placement=”left” button_on_hover=”off” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_button][et_pb_button button_text=”April 1, 2016″ _builder_version=”4.27.6″ _module_preset=”default” custom_button=”on” button_text_size=”16px” button_text_color=”#000000″ button_bg_color=”RGBA(255,255,255,0)” button_border_radius=”0px” button_icon=”||fa||400″ button_icon_color=”#35A4BB” button_icon_placement=”left” button_on_hover=”off” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.6″ _module_preset=”default” width=”65%” width_tablet=”80%” width_phone=”80%” width_last_edited=”on|phone” custom_padding=”0px||||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_image src=”https:\/\/www.erdheim-chester.org\/wp-content\/uploads\/2026\/07\/4th-ms.png” title_text=”4th ms” align=”center” force_fullwidth=”on” module_class=”past-event-image” _builder_version=”4.27.7″ _module_preset=”default” hover_enabled=”0″ border_radii=”on|10px|10px|10px|10px” global_colors_info=”{}” theme_builder_area=”post_content” custom_margin=”||10px||false|false” sticky_enabled=”0″][\/et_pb_image][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font_size=”14px” text_line_height=”-0.1em” text_orientation=”center” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

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Paris Medical Symposium Group Picture 2016<\/p>\n<\/div>\n<\/div>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.5″ _module_preset=”default” custom_padding=”0px||||false|false” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.27.6″ _module_preset=”default” width=”65%” width_tablet=”80%” width_phone=”80%” width_last_edited=”on|phone” custom_padding=”10px||||false|false” global_colors_info=”{}” width__hover_enabled=”off|desktop” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”||15px||false|false” border_width_bottom=”2px” border_color_bottom=”#35A4BB” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Symposium Summary<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”]The Erdheim-Chester Disease Global Alliance is pleased to provide the following summary of presentations given at this year\u2019s 4th Annual International ECD Medical Symposium, held on September 15, 2016, at H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re in Paris, France. The meeting allowed medical professionals to collaborate on ECD research, share medical findings, and discuss patient care. Thank you to this year\u2019s co-host, Professor Julien Haroche, MD, PhD; to all presenters who shared their data and expertise during panel discussions; to all attendees interested in learning more about ECD; and to everyone involved in planning and making this event a success. A special thank you to the volunteers who created this summary for the community and for the professionals who were unable to attend.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.6″ _module_preset=”default” width=”65%” width_tablet=”80%” width_phone=”80%” width_last_edited=”on|phone” custom_padding=”0px||0px||false|false” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” custom_margin=”||15px||false|false” border_width_bottom=”2px” border_color_bottom=”#14b8a6″ global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Programs with Symposium Agenda<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ module_class=”single-line-buttons ” _builder_version=”4.27.6″ _module_preset=”default” width=”65%” width_tablet=”80%” width_phone=”80%” width_last_edited=”on|phone” custom_padding=”||0px||false|false” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_3″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_image src=”https:\/\/www.erdheim-chester.org\/wp-content\/uploads\/2026\/06\/2016-Paris-MS-Program-Cover.jpg” title_text=”2016 Paris MS Program Cover” url=”https:\/\/www.erdheim-chester.org\/wp-content\/uploads\/2026\/06\/2016-MS-Program.pdf” url_new_window=”on” _builder_version=”4.27.6″ _module_preset=”default” border_radii=”on|8px|8px|8px|8px” border_width_all=”1px” border_color_all=”#c6c6c6″ global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.6″ _module_preset=”default” width=”65%” width_tablet=”80%” width_phone=”80%” width_last_edited=”on|phone” custom_padding=”||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” custom_margin=”||15px||false|false” border_width_bottom=”2px” border_color_bottom=”#35A4BB” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Presentations<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

The following presentations were given\u00a0at the 2016 meeting. Visit the\u00a0ECD Global Alliance YouTube channel<\/a>\u00a0for all published ECD related\u00a0videos<\/a>.<\/p>\n

[\/et_pb_text][et_pb_text module_class=”event-table” _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Presenter<\/th>Presentation Slides<\/th>Videos<\/th>\n<\/tr>\n<\/thead>\n
Prof. Julien Haroche, MD, PhD<\/td>Welcome<\/td>Welcome<\/a><\/td>\n<\/tr>\n
Omar Abdel-Wahab, MD, PhD and Benjamin Durham, MD;<\/td>Insights into the Cell-of-Origin of the Histiocytoses Using Patient-\u00ad\u2010Derived Xenograft Murine Models<\/a><\/td>Insights into the Cell-of-Origin of the Histiocytoses Using Patient-\u00ad\u2010Derived Xenograft Murine Models<\/a><\/td>\n<\/tr>\n
Lorenzo Dagna, MD, PhD<\/td>CCL18 in Erdheim-Chester Disease: Potential Implications in the Pathogenesis<\/td>Not available<\/td>\n<\/tr>\n
Matthew Collin, MD<\/td>The Hematopoietic Origin of Adult Histiocytosis<\/td>Not available<\/td>\n<\/tr>\n
Matthias Papo, MD<\/td>Erdheim-Chester disease is frequently associated with myeloproliferative neoplasms and myelodysplastic syndromes: a systematic clinical and molecular series of 189 patients<\/td>Not available<\/td>\n<\/tr>\n
Fleur Cohen-Aubart, MD & Wilfred Le Goff, MD<\/td>Marked alteration of circulating immune cells in Erdheim-Chester disease in a large single-center series of 46 patients<\/td>Not available<\/td>\n<\/tr>\n
Roei D. Mazor, MD<\/td>Biopsy Specimens of Erdheim-Chester Disease Patients<\/td>Not available<\/td>\n<\/tr>\n
Filip Janku, MD, PhD<\/td>Clinical Molecular Profiling to Detect Targetable Alterations in Archival Tumor Tissue and Cell-free DNA from Patients with Erdheim-Chester Disease<\/a><\/td>Clinical Molecular Profiling to Detect Targetable Alterations in Archival Tumor Tissue and Cell-free DNA from Patients with Erdheim-Chester Disease<\/a><\/td>\n<\/tr>\n
Tahla Munir, MD<\/td>A Single- centre Experience of Treating Adult Patients with Langerhans' cell
\nHistiocytosis and Erdheim Chester Disease; Sustained Response to Oral Methotrexate in Frontline and Relapsed Disease<\/td>		A Single- centre Experience of Treating Adult Patients with Langerhans' cellHistiocytosis and Erdheim Chester Disease; Sustained Response to Oral Methotrexate in Frontline and Relapsed Disease<\/a><\/td>\n<\/tr>\n
Achille Aouba, MD, PhD<\/td>Superior Efficacy and Equivalent Safety of Double-dose Anakinra in Erdheim-Chester Disease<\/td>Superior Efficacy and Equivalent Safety of Double-dose Anakinra in Erdheim-Chester Disease<\/a><\/td>\n<\/tr>\n
Tahla Munir, MD<\/td>Single Centre Experience of Treating Four Cases of Relapsed\/Refractory BRAF Mutated Erdheim Chester Disease (ECD) \/ Langerhan\u2019s Cell Histiocytosis(LCH) with Oral BRAF Inhibitor Vemurafenib<\/td>Single Centre Experience of Treating Four Cases of Relapsed\/Refractory BRAF Mutated Erdheim Chester Disease (ECD) \/ Langerhan\u2019s Cell Histiocytosis(LCH) with Oral BRAF Inhibitor Vemurafenib<\/a><\/td>\n<\/tr>\n
Fleur Cohen-Aubart, MD and Julien Haroche, MD, PhD<\/td>The LOVE trial: preliminary results<\/td>Not available<\/td>\n<\/tr>\n
Juvianee Estrada-Veras, MD<\/td>Dabrafenib and Trametinib as Potential Therapy in BRAF V600E Positive ErdheimChester Disease (ECD): Preliminary Results<\/td>Not available<\/td>\n<\/tr>\n
Eli L. Diamond, MD<\/td>Phase 2 Trial of Single-Agent Cobimetinib for Adults with Histiocytic Disorders: Preliminary Results<\/td>Not available<\/td>\n<\/tr>\n
Tahla Munir, MD<\/td>Dabrafenib in combination with Trametinib is effective in treatment of refractory BRAF mutated mixed histiocytic disease- A Case report<\/td>Dabrafenib in combination with Trametinib is effective in treatment of refractory BRAF mutated mixed histiocytic disease- A Case report<\/a><\/td>\n<\/tr>\n
Diana Melo, MD<\/td>Spectrum of Cardiovascular Involvement in Erdheim-Chester Disease Evaluated by Multimodality Imaging<\/td>Not available<\/td>\n<\/tr>\n
Mark Heaney, MD, Julien Haroche, MD, PhD, Eli L. Diamond, MD, Matthew Collin, MD, Lorenzo Dagna, MD, PhD<\/td>Panel Discussion: ECD Patient Registry: Community Tool for Research<\/td>Panel Discussion: ECD Patient Registry: Community Tool for Research<\/a><\/td>\n<\/tr>\n
Augusto Vaglio, MD, PhD, Juvianee Estrada-Veras, MD, Filip Janku, MD, PhD, Omar Abdel-Wahab, MD, PhD, Javier Martin, MD, PhD<\/td>Panel Discussion: Proposed ECD GWAS Study<\/a><\/td>Panel Discussion: Proposed ECD GWAS Study<\/a><\/td>\n<\/tr>\n
Corrado Campochiaro, MD<\/td>Management of ECD Symptoms and Side Effects of Treatments<\/a><\/td>Management of ECD Symptoms and Side Effects of Treatments<\/a><\/td>\n<\/tr>\n
Giulio Cavalli, MD<\/td>Adult Onset (Infratentorial) Leukoencephalopathy as Presenting Manifestation of Erdheim-Chester Disease<\/a><\/td>Adult Onset (Infratentorial) Leukoencephalopathy as Presenting Manifestation of Erdheim-Chester Disease<\/a><\/td>\n<\/tr>\n
Carine Courtillot, MD<\/td>Endocrine manifestations in Erdheim-Chester disease<\/a><\/td>Endocrine manifestations in Erdheim-Chester disease<\/a><\/td>\n<\/tr>\n
Benjamin Durham, MD<\/td>Insights into the Cell-of-Origin of the Histiocytoses Using Patient-Derived Xenograft Murine Models<\/a><\/td>Insights into the Cell-of-Origin of the Histiocytoses Using Patient-Derived Xenograft Murine Models<\/a><\/td>\n<\/tr>\n
Marina Ferrarini, MD<\/td>Tailoring Treatment for Erdheim-Chester Disease: Focus on ECD<\/a><\/td>Tailoring Treatment for Erdheim-Chester Disease: Focus on ECD<\/a><\/td>\n<\/tr>\n
Ronald Go, MD<\/td>Efficacy of Cladribine (2-CdA) in the Treatment of Erdheim-Chester Disease (ECD)<\/a><\/td>Efficacy of Cladribine (2-CdA) in the Treatment of Erdheim-Chester Disease (ECD)<\/a><\/td>\n<\/tr>\n
Filip Janku, MD, PhD<\/td>Encouraging activity of MEK inhibitor trametinib in patients with Erdheim-Chester disease irrespective of BRAF mutation statusClinical Molecular Profiling to Detect Targetable Alterations in Archival Tumor Tissue and Cell-free DNA from Patients with Erdheim-Chester Disease<\/a><\/td>Encouraging activity of MEK inhibitor trametinib in patients with Erdheim-Chester disease irrespective of BRAF mutation statusClinical Molecular Profiling to Detect Targetable Alterations in Archival Tumor Tissue and Cell-free DNA from Patients with Erdheim-Chester Disease<\/a><\/td>\n<\/tr>\n
Javier Martin, MD, PhD<\/td>Future Genetic Studies in Erdheim-Chester disease \u2013 GWAS Study<\/a><\/td>Future Genetic Studies in Erdheim-Chester disease \u2013 GWAS Study<\/a><\/td>\n<\/tr>\n
Kenneth McClain, MD, PhD<\/td>Elevated CSF Osteopontin and Circulating Cells with BRAF Mutations in Patients with Langerhans Cell Histiocytosis-Associated Neurodegeneration -A Model for ECD?<\/a><\/td>Elevated CSF Osteopontin and Circulating Cells with BRAF Mutations in Patients with Langerhans Cell Histiocytosis-Associated Neurodegeneration -A Model for ECD?<\/a><\/td>\n<\/tr>\n
Augusto Vaglio, MD, PhD<\/td>MRI evidence of cardiac involvement in Erdheim-Chester disease<\/a><\/td>MRI evidence of cardiac involvement in Erdheim-Chester disease<\/a><\/td>\n<\/tr>\n
Julien Haroche, MD, PhD & Kathleen Brewer<\/td>Closing<\/td>Not available<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n

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