{"id":54905,"date":"2025-04-29T05:24:45","date_gmt":"2025-04-29T09:24:45","guid":{"rendered":"https:\/\/www.erdheim-chester.org\/%ce%b1%ce%bd%ce%b9%cf%87%ce%bd%ce%b5%cf%8d%ce%bf%ce%bd%cf%84%ce%b1%cf%82-%cf%84%ce%b9%cf%82-%cf%81%ce%af%ce%b6%ce%b5%cf%82-%cf%84%ce%b7%cf%82-erdheim-chester-disease\/"},"modified":"2025-08-23T17:14:05","modified_gmt":"2025-08-23T21:14:05","slug":"%ce%b1%ce%bd%ce%b9%cf%87%ce%bd%ce%b5%cf%8d%ce%bf%ce%bd%cf%84%ce%b1%cf%82-%cf%84%ce%b9%cf%82-%cf%81%ce%af%ce%b6%ce%b5%cf%82-%cf%84%ce%b7%cf%82-erdheim-chester-disease","status":"publish","type":"post","link":"https:\/\/www.erdheim-chester.org\/el\/%ce%b1%ce%bd%ce%b9%cf%87%ce%bd%ce%b5%cf%8d%ce%bf%ce%bd%cf%84%ce%b1%cf%82-%cf%84%ce%b9%cf%82-%cf%81%ce%af%ce%b6%ce%b5%cf%82-%cf%84%ce%b7%cf%82-erdheim-chester-disease\/","title":{"rendered":"\u0391\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b9\u03c2 \u03c1\u03af\u03b6\u03b5\u03c2 \u03c4\u03b7\u03c2 Erdheim-Chester Disease"},"content":{"rendered":"<p>\u03a4\u03bf Erdheim-Chester Disease Global Alliance (ECDGA) \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c4\u03b9\u03bc\u03ae \u03bd\u03b1 \u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03bb\u03b5\u03cd\u03ba\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03c5\u03c3\u03c4\u03b7\u03c1\u03af\u03c9\u03bd \u03c0\u03af\u03c3\u03c9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd Erdheim-Chester Disease (ECD). \u0388\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c5\u03bd\u03b1\u03c1\u03c0\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 \u03ad\u03c1\u03b3\u03b1 \u03bc\u03b1\u03c2, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b2\u03c1\u03b1\u03b2\u03b5\u03cd\u03c4\u03b7\u03ba\u03b5 \u03c4\u03bf 2023 \u03bc\u03b5 \u03b4\u03b9\u03b5\u03c4\u03ae \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 200.000 \u03b4\u03bf\u03bb\u03b1\u03c1\u03af\u03c9\u03bd, \u03b4\u03b9\u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Dr. Matthew Collin \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 Dr. Jyoti Nangalia \u03ba\u03b1\u03b9 Dr. Eli Diamond. \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03bf\u03c5\u03c2, <em>&#8220;Inferring the Origin of Erdheim-Chester Disease from Phylogenetic Mapping<\/em> &#8220;, \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03bd\u03ad\u03b5\u03c2 \u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03c3\u03c5\u03bd\u03b7\u03b8\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03b1\u03b8\u03b9\u03ac \u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b8\u03ad\u03c4\u03bf\u03c5\u03bd \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2: \u0391\u03c0\u03cc \u03c0\u03bf\u03cd \u03c0\u03c1\u03bf\u03ae\u03bb\u03b8\u03b5 \u03b7 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03ac \u03bc\u03bf\u03c5; \u03a0\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9\u03c1\u03cc \u03c4\u03b7\u03bd \u03ad\u03c7\u03c9; \u0398\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b5\u03af\u03c7\u03b5 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c6\u03b8\u03b5\u03af \u03bd\u03c9\u03c1\u03af\u03c4\u03b5\u03c1\u03b1;    <\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03c6\u03b9\u03bb\u03cc\u03b4\u03bf\u03be\u03bf \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b9\u03ce\u03ba\u03b5\u03b9 \u03ba\u03ac\u03c4\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 ECD- \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03bd\u03b1 \u03c4\u03bf \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03c4\u03cc\u03bc\u03bf\u03c5.<\/p>\n<h3>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c6\u03c5\u03bb\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c7\u03b1\u03c1\u03c4\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7;<\/h3>\n<p>\u03a3\u03c4\u03bf \u03b5\u03c0\u03af\u03ba\u03b5\u03bd\u03c4\u03c1\u03bf \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>\u03c6\u03c5\u03bb\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c7\u03b1\u03c1\u03c4\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7<\/strong>, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae \u03b5\u03bd\u03cc\u03c2 &#8220;\u03b3\u03b5\u03bd\u03b5\u03b1\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03b4\u03ad\u03bd\u03c4\u03c1\u03bf\u03c5&#8221; \u03c4\u03c9\u03bd \u03b2\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2. \u0397 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03bb\u03b9\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b2\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03bc\u03c5\u03b5\u03bb\u03cc \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd \u03b5\u03bd\u03cc\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf, \u03c4\u03b7\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03ce\u03bc\u03b1\u03c4\u03cc\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03cc \u03bb\u03b5\u03c0\u03c4\u03ce\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ce\u03bd DNA \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2. \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c7\u03c1\u03bf\u03bd\u03bf\u03b4\u03b9\u03ac\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5, \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03cc\u03c4\u03b5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 -\u03cc\u03c0\u03c9\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c4\u03bf ECD.  <\/p>\n<p>\u0391\u03c5\u03c4\u03ae \u03b7 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03b4\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03bf\u03bd\u03b5\u03c2 \u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 <em>&#8220;\u03c7\u03c1\u03bf\u03bd\u03bf\u03bb\u03bf\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd&#8221;<\/em> \u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c4\u03bf ECD \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ae\u03c3\u03bf\u03c5\u03bd \u03c0\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9\u03c1\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b5\u03b9\u03bd\u03b1\u03bd \u03c3\u03b5 \u03bb\u03b1\u03bd\u03b8\u03ac\u03bd\u03bf\u03c5\u03c3\u03b1 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03b9\u03bd \u03b5\u03be\u03b5\u03bb\u03b9\u03c7\u03b8\u03bf\u03cd\u03bd \u03c3\u03b5 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1. \u03a4\u03bf\u03c5\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03ae\u03c3\u03bf\u03c5\u03bd \u03b1\u03bd \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b2\u03bf\u03ae\u03b8\u03b7\u03c3\u03b1\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03bf\u03b9 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b5\u03c0\u03b7\u03c1\u03ad\u03b1\u03c3\u03b1\u03bd \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03c1\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5. <\/p>\n<h3>\u03a0\u03c1\u03ce\u03b9\u03bc\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1: ECD \u03b5\u03c0\u03af \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b5\u03c2<\/h3>\n<p>\u039c\u03ad\u03c7\u03c1\u03b9 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae\u03c2, \u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03bf\u03c5 Dr. Collin \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 Dr. Nangalia \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ae\u03c3\u03b5\u03b9 \u03b4\u03cd\u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, \u03c0\u03bf\u03bb\u03c5\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae ECD\/LCH. \u03a4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03cd\u03bf \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c0\u03bf\u03c5 \u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf ECD \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b1\u03c4\u03b1 \u03c0\u03c1\u03bf\u03ae\u03bb\u03b8\u03b5 <strong>\u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>. \u039a\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03af\u03c7\u03b1\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ad\u03c2 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1-\u03ba\u03bb\u03b5\u03b9\u03b4\u03b9\u03ac, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 <strong>KRAS, NRAS \u03ba\u03b1\u03b9 BRAF<\/strong>, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03bd \u03c3\u03b5 \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03ba\u03bb\u03ac\u03b4\u03bf\u03c5\u03c2 \u03c4\u03c9\u03bd \u03c6\u03c5\u03bb\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03bf\u03c5\u03c2 \u03b4\u03ad\u03bd\u03c4\u03c1\u03c9\u03bd. \u0395\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03cc\u03c4\u03b9 \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b5\u03ba\u03c4\u03c5\u03bb\u03af\u03c7\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c5\u03c0\u03cc\u03b2\u03b1\u03b8\u03c1\u03bf <strong>\u03b4\u03b9-\u03b1\u03bb\u03bb\u03b7\u03bb\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd TET2<\/strong>, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c7\u03b8\u03b7\u03ba\u03b1\u03bd \u03c0\u03bf\u03bb\u03cd \u03bd\u03c9\u03c1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b7 \u03b6\u03c9\u03ae.   <\/p>\n<p>\u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03c4\u03bf ECD, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03c7\u03b8\u03b5\u03af \u03b5\u03c0\u03af \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b5\u03c2 \u03bc\u03b5 \u03c4\u03c1\u03cc\u03c0\u03bf \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03bf \u03bc\u03b5 <strong>\u03c4\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1<\/strong>, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c0\u03b9\u03bf \u03c3\u03c5\u03bd\u03b7\u03b8\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03b9 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2. \u03a4\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03b1\u03c5\u03c4\u03cc \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 ECD \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b3\u03b5\u03c6\u03c5\u03c1\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ad\u03c2 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2. <\/p>\n<h3>\u039a\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5<\/h3>\n<p>\u03a4\u03bf \u03ad\u03c1\u03b3\u03bf \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03c4\u03c1\u03af\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03b5\u03c1\u03c9\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1:<\/p>\n<ol>\n<li><strong>\u03a0\u03cc\u03c4\u03b5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c4\u03bf ECD \u03ba\u03b1\u03b9 \u03c0\u03cc\u03c3\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1;<\/strong><br \/>\n&#8211; \u03a4\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03c4\u03b1\u03c1\u03ba\u03c4\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bb\u03b1\u03bd\u03b8\u03ac\u03bd\u03bf\u03c5\u03c3\u03b1 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ae \u03ba\u03b1\u03b9 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b5\u03c2 \u03c0\u03c1\u03b9\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1.<\/li>\n<li><strong>\u03a0\u03ce\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 BRAFV600E \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 TET2;<\/strong><br \/>\n&#8211; \u0397 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b4\u03b9\u03b1\u03c0\u03af\u03c3\u03c4\u03c9\u03c3\u03b5 \u03cc\u03c4\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 MAPK \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd <em>\u03c3\u03b5<\/em> \u03ba\u03bb\u03ce\u03bd\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c4\u03b7\u03c2 TET2, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03ba\u03ac\u03b8\u03b5 \u03bc\u03af\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03c3\u03b5 \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b1, \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03c5\u03c0\u03bf\u03b8\u03ad\u03c3\u03b5\u03b9\u03c2.<\/li>\n<li><strong>\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bd\u03ad\u03b5\u03c2, \u03bc\u03b7 \u03b1\u03bd\u03b1\u03ba\u03b1\u03bb\u03c5\u03c6\u03b8\u03b5\u03af\u03c3\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 ECD \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ad\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2;<\/strong><br \/>\n&#8211; \u0391\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03b1\u03ba\u03cc\u03bc\u03b7 \u03bd\u03ad\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2-\u03bf\u03b4\u03b7\u03b3\u03bf\u03af, \u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03c4\u03b1\u03b9.<\/li>\n<\/ol>\n<h3>\u0391\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03ba\u03bb\u03ae\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b2\u03ae\u03bc\u03b1\u03c4\u03b1<\/h3>\n<p>\u039c\u03b9\u03b1 \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03b5\u03b9 \u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03bd\u03cc\u03c3\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1, \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03ae \u03c3\u03c4\u03bf \u03bc\u03c5\u03b5\u03bb\u03cc \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b1\u03c1\u03b1\u03b9\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03c9\u03bd \u03ba\u03bb\u03ce\u03bd\u03c9\u03bd \u03b2\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03ce\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03b7 <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5<\/strong>, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c6\u03ac\u03bb\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03cc \u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03bf.  <\/p>\n<p>\u03a3\u03c4\u03b7\u03bd \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03c6\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ad\u03c1\u03b3\u03bf\u03c5, \u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03bf\u03c5 Dr. Collin \u03b8\u03b1 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03b7\u03c2, \u03b8\u03b1 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bb\u03ae\u03c8\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (\u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03bf\u03c5 EHA \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bf\u03c3\u03af\u03bf\u03c5 ECDGA ) \u03ba\u03b1\u03b9 \u03b8\u03b1 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2. \u03a3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b5\u03af\u03be\u03bf\u03c5\u03bd \u03c0\u03ce\u03c2 \u03c4\u03bf ECD \u03b1\u03bd\u03b1\u03b4\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b9\u03b1\u03c2 \u03b1\u03c1\u03b3\u03ae\u03c2, \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03be\u03b5\u03bb\u03b9\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c1\u03c7\u03af\u03c3\u03bf\u03c5\u03bd \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b5\u03c2 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. <\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03b1\u03c5\u03c4\u03ae \u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/h3>\n<p>\u039c\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b9\u03c3\u03c4\u03bf\u03c1\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 ECD, \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b1\u03bd\u03bf\u03af\u03be\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03cc\u03c1\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd <strong>\u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7<\/strong>, \u03c4\u03bf\u03bd <strong>\u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1\u03c4\u03af \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2. \u039f\u03b9 \u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03b1\u03c0\u03bf\u03ba\u03c4\u03b7\u03b8\u03bf\u03cd\u03bd \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03c5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b3\u03b9\u03b1\u03c4\u03c1\u03bf\u03cd\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf ECD \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf, \u03bc\u03bf\u03b9\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b4\u03bf\u03cd\u03c2 \u03bc\u03b5 \u03c0\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03bf\u03cd\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2<\/strong>, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b1\u03c7\u03cd\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2. <\/p>\n<p>\u03a3\u03c4\u03bf ECDGA, \u03c0\u03b9\u03c3\u03c4\u03b5\u03cd\u03bf\u03c5\u03bc\u03b5 \u03c3\u03c4\u03b7 \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03bc\u03bf\u03c1\u03c6\u03ce\u03bd\u03b5\u03b9 \u03b6\u03c9\u03ad\u03c2. \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03ad\u03c1\u03b3\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c6\u03b9\u03ba\u03c4\u03cc \u03bc\u03cc\u03bd\u03bf \u03c7\u03ac\u03c1\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c6\u03bf\u03c3\u03af\u03c9\u03c3\u03b7 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03bf \u0394\u03c1 Collin \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 \u03c4\u03c9\u03bd \u03b4\u03c9\u03c1\u03b7\u03c4\u03ce\u03bd \u03bc\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1\u03c2 \u03ba\u03bf\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03ac\u03c2 \u03bc\u03b1\u03c2. <\/p>\n<hr>\n<p><strong>\u03a4\u03bf Erdheim-Chester Disease Global Alliance (ECDGA) \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ad\u03c2, \u03b4\u03b9\u03b1\u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2. \u038c\u03bb\u03bf \u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2. \u03a0\u03b1\u03c1\u03b1\u03ba\u03b1\u03bb\u03bf\u03cd\u03bc\u03b5 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b5\u03af\u03c4\u03b5 \u03ad\u03bd\u03b1\u03bd \u03c0\u03ac\u03c1\u03bf\u03c7\u03bf \u03c5\u03b3\u03b5\u03b9\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b5\u03c1\u03af\u03b8\u03b1\u03bb\u03c8\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b5\u03c2.  <\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u03a4\u03bf Erdheim-Chester Disease Global Alliance (ECDGA) \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c4\u03b9\u03bc\u03ae \u03bd\u03b1 \u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03bb\u03b5\u03cd\u03ba\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03c5\u03c3\u03c4\u03b7\u03c1\u03af\u03c9\u03bd \u03c0\u03af\u03c3\u03c9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd Erdheim-Chester Disease (ECD). \u0388\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":48289,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_wds_title":"","_wds_metadesc":"","_wds_focus-keywords":"","_wds_meta-robots-adv":"","_wds_meta-robots-noindex":false,"_wds_meta-robots-nofollow":false,"_wds_meta-robots-index":false,"_wds_meta-robots-follow":false,"_wds_autolinks-exclude":false,"_wds_canonical":"","_wds_redirect":"","_wds_opengraph":[],"_wds_twitter":[],"cybocfi_hide_featured_image":"","wds_primary_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[424],"tags":[],"class_list":["post-54905","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ecdga-"],"_links":{"self":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/posts\/54905","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/comments?post=54905"}],"version-history":[{"count":0,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/posts\/54905\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/media\/48289"}],"wp:attachment":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/media?parent=54905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/categories?post=54905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/tags?post=54905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}