{"id":105391,"date":"2025-10-27T08:11:56","date_gmt":"2025-10-27T13:11:56","guid":{"rendered":"https:\/\/www.erdheim-chester.org\/%ce%bd%ce%ad%ce%b5%cf%82-%ce%b5%ce%bb%cf%80%ce%af%ce%b4%ce%b5%cf%82-%cf%83%cf%84%ce%b7-%cf%83%cf%84%ce%bf%cf%87%ce%b5%cf%85%ce%bc%ce%ad%ce%bd%ce%b7-%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1\/"},"modified":"2025-10-27T08:40:41","modified_gmt":"2025-10-27T13:40:41","slug":"%ce%bd%ce%ad%ce%b5%cf%82-%ce%b5%ce%bb%cf%80%ce%af%ce%b4%ce%b5%cf%82-%cf%83%cf%84%ce%b7-%cf%83%cf%84%ce%bf%cf%87%ce%b5%cf%85%ce%bc%ce%ad%ce%bd%ce%b7-%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1","status":"publish","type":"post","link":"https:\/\/www.erdheim-chester.org\/el\/%ce%bd%ce%ad%ce%b5%cf%82-%ce%b5%ce%bb%cf%80%ce%af%ce%b4%ce%b5%cf%82-%cf%83%cf%84%ce%b7-%cf%83%cf%84%ce%bf%cf%87%ce%b5%cf%85%ce%bc%ce%ad%ce%bd%ce%b7-%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1\/","title":{"rendered":"\u039d\u03ad\u03b5\u03c2 \u03b5\u03bb\u03c0\u03af\u03b4\u03b5\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b9\u03c3\u03c4\u03b9\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7"},"content":{"rendered":"<div>\n<p class=\"x_MsoNormal\"><span data-olk-copy-source=\"MessageBody\">\u039c\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c0\u03cc <b>\u03c4\u03bf \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 Memorial Sloan Kettering \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9<\/b> \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03c3\u03c7\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 <b>ulixertinib,<\/b> \u03b5\u03bd\u03cc\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd ERK, \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03bc\u03bf\u03c1\u03c6\u03ce\u03bd <b>\u03b9\u03c3\u03c4\u03b9\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7\u03c2, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2<\/b> <b>\u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 Erdheim-Chester Disease (ECD).<\/b><\/span><\/p>\n<p class=\"x_MsoNormal\">\u039c\u03b5 \u03b5\u03c0\u03b9\u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03c4\u03bf\u03bd Dr. Eli Diamond, \u03bc\u03ad\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03a3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u0395\u03c0\u03b9\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03c4\u03bf\u03c5 ECDGA, \u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03b1\u03c5\u03c4\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b5\u03af \u03ad\u03bd\u03b1 \u03c3\u03c5\u03bd\u03b1\u03c1\u03c0\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03b2\u03ae\u03bc\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03b5\u03bc\u03c0\u03c1\u03cc\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03b9\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd MAPK. \u0393\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bf\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03ac \u03bc\u03b1\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03bf Joey, \u03bc\u03ad\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 ECDGA, \u03c4\u03bf\u03c5 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5 \u03c4\u03bf \u03c4\u03b1\u03be\u03af\u03b4\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03bc\u03b1\u03c2 \u03b5\u03bc\u03c0\u03bd\u03ad\u03b5\u03b9, \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b1\u03ba\u03b1\u03bb\u03cd\u03c8\u03b5\u03b9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03cd\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03cd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf. \u03a0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03b5\u03bb\u03c0\u03af\u03b4\u03b1.  <\/p>\n<p class=\"x_MsoNormal\">\u0394\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf MSKCC:<br \/>\n https:\/\/www.mskcc.org\/news\/targeted-therapy-drug-ulixertinib-for-histiocytosis-blood<\/p>\n<p class=\"x_MsoNormal\">\u03a0\u03c1\u03cc\u03c3\u03b2\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ae\u03c1\u03b5\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03cc \u03ac\u03c1\u03b8\u03c1\u03bf \u03c3\u03c4\u03bf <i>Cancer Cell:<\/i><br \/>\n https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1535610825004064<\/p>\n<p class=\"x_MsoNormal\">\u03a3\u03c4\u03bf ECDGA, \u03b5\u03af\u03bc\u03b1\u03c3\u03c4\u03b5 \u03c5\u03c0\u03b5\u03c1\u03ae\u03c6\u03b1\u03bd\u03bf\u03b9 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03ba\u03b1\u03b9 \u03bc\u03bf\u03b9\u03c1\u03b1\u03b6\u03cc\u03bc\u03b1\u03c3\u03c4\u03b5 \u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03b1\u03c2 \u03c6\u03ad\u03c1\u03bd\u03b5\u03b9 \u03c0\u03b9\u03bf \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b5\u03c1\u03af\u03b8\u03b1\u03bb\u03c8\u03b7, \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9, \u03ba\u03ac\u03c0\u03bf\u03b9\u03b1 \u03bc\u03ad\u03c1\u03b1, \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/p>\n<p><em>\u03a4\u03bf Erdheim-Chester Disease Global Alliance (ECDGA) \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ad\u03c2, \u03b4\u03b9\u03b1\u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2. \u038c\u03bb\u03bf \u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2. \u03a0\u03b1\u03c1\u03b1\u03ba\u03b1\u03bb\u03bf\u03cd\u03bc\u03b5 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b5\u03af\u03c4\u03b5 \u03ad\u03bd\u03b1\u03bd \u03c0\u03ac\u03c1\u03bf\u03c7\u03bf \u03c5\u03b3\u03b5\u03b9\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b5\u03c1\u03af\u03b8\u03b1\u03bb\u03c8\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b5\u03c2.  <\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u039c\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 Memorial Sloan Kettering \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03c3\u03c7\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 ulixertinib, \u03b5\u03bd\u03cc\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd ERK, \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03bc\u03bf\u03c1\u03c6\u03ce\u03bd \u03b9\u03c3\u03c4\u03b9\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7\u03c2 &#8211; \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 Erdheim-Chester Disease (ECD).<\/p>\n","protected":false},"author":14,"featured_media":105371,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_wds_title":"","_wds_metadesc":"","_wds_focus-keywords":"","_wds_meta-robots-adv":"","_wds_meta-robots-noindex":false,"_wds_meta-robots-nofollow":false,"_wds_meta-robots-index":false,"_wds_meta-robots-follow":false,"_wds_autolinks-exclude":false,"_wds_canonical":"","_wds_redirect":"","_wds_opengraph":[],"_wds_twitter":[],"cybocfi_hide_featured_image":"","wds_primary_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[424],"tags":[533,2614,5115,5111,5117,5119,5121,4317,5125,5077,5123,1169,5114,3509,5109],"class_list":["post-105391","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ecdga-","tag-ecdawareness-el","tag-elidiamond-el","tag-erdheim-chesterdisease","tag-erkinhibitor","tag-mapkpathway","tag-memorialsloankettering","tag-precisionmedicine","tag-rarediseaseresearch-el","tag-researchbreakthrough","tag-ulixertinib","tag---2","tag-1169","tag-3509","tag-5109"],"_links":{"self":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/posts\/105391","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/comments?post=105391"}],"version-history":[{"count":0,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/posts\/105391\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/media\/105371"}],"wp:attachment":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/media?parent=105391"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/categories?post=105391"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/tags?post=105391"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}