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background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2\/\u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 ECD \u03c0\u03bf\u03c5 \u03b4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 ECD.<\/p>\n<p>\u0391\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03b5\u03c3\u03b5\u03af\u03c2 \u03ae \u03c4\u03bf \u03b1\u03b3\u03b1\u03c0\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03b1\u03c2 \u03c0\u03c1\u03cc\u03c3\u03c9\u03c0\u03bf \u03b4\u03b5\u03bd \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c3\u03c4\u03b5 \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd\/\u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd, \u03b5\u03c3\u03b5\u03af\u03c2 \u03ae \u03bf \u03b8\u03b5\u03c1\u03ac\u03c0\u03c9\u03bd \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03c3\u03b1\u03c2 \u03b5\u03bd\u03b8\u03b1\u03c1\u03c1\u03cd\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b9\u03bb\u03ae\u03c3\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\/\u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0391\u03c5\u03c4\u03cc \u03b8\u03b1 \u03c3\u03b1\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c8\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03c9\u03c6\u03b5\u03bb\u03b7\u03b8\u03b5\u03af\u03c4\u03b5 \u03b1\u03c0\u03cc \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03ba\u03bf\u03c1\u03c5\u03c6\u03b1\u03af\u03b5\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c4\u03b1\u03c7\u03ad\u03c9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03b1\u03bb\u03bb\u03cc\u03bc\u03b5\u03bd\u03bf \u03ba\u03cc\u03c3\u03bc\u03bf \u03c4\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd ECD. <\/p>\n<h3>\u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/h3>\n<p>ECD \u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2. \u039f\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03b4\u03b5\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03b6\u03bf\u03c5\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd \u03bc\u03b9\u03b1 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03bb\u03b5\u03b3\u03c7\u03b8\u03b5\u03af \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b9\u03b1\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2. \u03a4\u03cc\u03c3\u03bf \u03bf\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b7 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03ac\u03b8\u03bf\u03c5\u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf ECD.  <\/p>\n<h3>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2<\/h3>\n<p>\u0395\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 ECD. \u03a4\u03b1 \u03c0\u03bb\u03b5\u03bf\u03bd\u03b5\u03ba\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ac\u03c3\u03c7\u03b5\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd: <\/p>\n<ol>\n<li>\u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03ae \u03c4\u03bc\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03c9\u03c1\u03b5\u03ac\u03bd \u03c3\u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae. (\u039c\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2, \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1\u03be\u03af\u03b4\u03b9\u03b1. \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bd\u03b1 \u03c1\u03c9\u03c4\u03bf\u03cd\u03bd \u03c0\u03bf\u03b9\u03b5\u03c2 \u03b4\u03b1\u03c0\u03ac\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae). <\/li>\n<li>\u03a4\u03b1 \u03c1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03ac. (\u038c\u03c0\u03bf\u03c5 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b3\u03bd\u03c9\u03c3\u03c4\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b5\u03af \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03ad\u03c4\u03c1\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2). <\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac, \u03b5\u03ac\u03bd \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf, \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03bb\u03ad\u03be\u03b9\u03bc\u03bf\u03c2 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ac\u03c3\u03c7\u03b5\u03b9 \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0393\u03b9\u03b1 \u03c4\u03bf \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b5\u03c0\u03c9\u03c6\u03b5\u03bb\u03ad\u03c2 \u03bd\u03b1 \u03c1\u03c9\u03c4\u03ac\u03c4\u03b5 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03ba\u03ac\u03b8\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ac\u03c3\u03c7\u03b5\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b5\u03bd\u03b8\u03b1\u03c1\u03c1\u03cd\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9 \u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03bb\u03ad\u03be\u03b9\u03bc\u03bf\u03c2 \u03b1\u03bd\u03ac \u03c0\u03ac\u03c3\u03b1 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae, \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5.  <\/li>\n<\/ol>\n<p>\u03a4\u03b1 \u03c0\u03bb\u03b5\u03bf\u03bd\u03b5\u03ba\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03bf\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 ECD \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03cc \u03c4\u03b7\u03c2 \u03cc\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd:<\/p>\n<ol>\n<li>\u039f\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA\/\u03c4\u03b7\u03bd \u03ba\u03c5\u03b2\u03ad\u03c1\u03bd\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 ECD. \u039c\u03b5 \u03c4\u03b7\u03bd \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03b2\u03ad\u03c1\u03bd\u03b7\u03c3\u03b7\u03c2, \u03bf\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03c4\u03ad\u03c2 \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03bd\u03b1 \u03b5\u03b3\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. <\/li>\n<li>\u039c\u03b5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd ECD, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03b7\u03b8\u03b5\u03af \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c0\u03c1\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd \u03cc\u03c0\u03c9\u03c2 (\u03b1) \u03c0\u03cc\u03c3\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03cc \u03c0\u03bf\u03b9\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2, (\u03b2) \u03c0\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9\u03c1\u03cc \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, (\u03b3) \u03c0\u03bf\u03b9\u03b5\u03c2, \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd, \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c8\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03ba.\u03bb\u03c0.   <\/li>\n<\/ol>\n<h3><strong>\u039c\u03ac\u03b8\u03b5\u03c4\u03b5 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ECD \u039f\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03b5\u03ac\u03bd \u03bc\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 ECD. \u039f\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd 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ECD \u039f\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u03c3\u03b5 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ac \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03b9\u03b1\u03c4\u03c1\u03b5\u03af\u03b1 \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u0395\u03c5\u03c1\u03ce\u03c0\u03b7.    <\/p>\n<h3>\u039f\u03c6\u03ad\u03bb\u03b7<\/h3>\n<p>\u0397 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ac \u03bf\u03c6\u03ad\u03bb\u03b7. \u0393\u03b9\u03b1 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\u03c4\u03bf\u03c5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7 \u03bf\u03c0\u03bf\u03b9\u03b1\u03c3\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03c0\u03c1\u03b9\u03bd \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03ae\u03c3\u03b5\u03c4\u03b5 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ac\u03c3\u03c7\u03b5\u03c4\u03b5 \u03c3\u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae. \u03a3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03b1\u03c2 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd. <\/p>\n<p>\u039c\u03cc\u03bb\u03b9\u03c2 \u03bf FDA \u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c2, \u03bf \u03af\u03b4\u03b9\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03bf \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03bc\u03b9\u03b1 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c4\u03b9\u03ba\u03ad\u03c4\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5. \u0397 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03c0\u03bf\u03bb\u03cd 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\u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf.  <\/p>\n<h3>\u03a7\u03c1\u03ae\u03c3\u03b7 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b5\u03c0\u03b9\u03c3\u03ae\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2<\/h3>\n<p>\u03a3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391, \u03cc\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03c1\u03cc\u03c0\u03bf \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA \u03b5\u03c4\u03b9\u03ba\u03ad\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5, \u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7 &#8220;\u03b5\u03ba\u03c4\u03cc\u03c2 \u03b5\u03c0\u03b9\u03c3\u03ae\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2&#8221;. \u0391\u03c5\u03c4\u03cc \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b5\u03af\u03bd\u03b1\u03b9: <\/p>\n<ul>\n<li>\u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 \u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7<\/li>\n<li>\u0394\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03c4\u03c1\u03cc\u03c0\u03bf (\u03cc\u03c0\u03c9\u03c2 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b4\u03c1\u03bf\u03bc\u03ae)<\/li>\n<li>\u03a7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ae \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c4\u03b9\u03ba\u03ad\u03c4\u03b1<\/li>\n<\/ul>\n<p>\u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 ECD \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA \u03ba\u03b1\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03cc\u03c7\u03b9. \u0391\u03c5\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf ECD \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 off-label \u03c7\u03c1\u03ae\u03c3\u03b7. \u039f\u03b9 off-label ECD \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 ECD \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 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\u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03bf\u03b9. \u0395\u03ac\u03bd \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03c3\u03b1\u03c2 \u03c3\u03ba\u03ad\u03c6\u03c4\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c3\u03ae\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2, \u03b5\u03c3\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03c3\u03b1\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03bb\u03ad\u03b3\u03be\u03b5\u03c4\u03b5 \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03c3\u03b1\u03c2. \u0395\u03ac\u03bd \u03c3\u03b1\u03c2 \u03b1\u03c1\u03bd\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9 \u03b5\u03ac\u03bd \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03c3\u03c4\u03b5\u03af\u03bb\u03b5\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03ae \u03b1\u03bd\u03c4\u03af\u03b3\u03c1\u03b1\u03c6\u03b1 \u03ac\u03c1\u03b8\u03c1\u03c9\u03bd \u03b1\u03c0\u03cc \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ac \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ac \u03ae \u03ac\u03bb\u03bb\u03b5\u03c2 \u03ad\u03b3\u03ba\u03c5\u03c1\u03b5\u03c2 \u03c0\u03b7\u03b3\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b5\u03c4\u03b9\u03ba\u03ad\u03c4\u03b1\u03c2. \u0397 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03a3\u03c5\u03bc\u03bc\u03b1\u03c7\u03af\u03b1 ECD \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c5\u03c7\u03ac\u03c1\u03b9\u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc. (\u03a0\u03b1\u03c1\u03b1\u03ba\u03b1\u03bb\u03bf\u03cd\u03bc\u03b5 \u03b1\u03bd\u03b1\u03c4\u03c1\u03ad\u03be\u03c4\u03b5 \u03c3\u03c4\u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03bc\u03b1\u03c2 <a href=\"https:\/\/www.erdheim-chester.org\/el\/%ce%ba%ce%b1%cf%84%ce%ac%ce%b8%ce%b5%cf%83%ce%b7-%cf%80%cf%81%ce%bf%cf%83%cf%86%cf%85%ce%b3%cf%8e%ce%bd-%cf%80%ce%bb%ce%b7%cf%81%cf%89%cf%84%cf%8e%ce%bd\/\">\u03a5\u03c0\u03bf\u03b2\u03bf\u03bb\u03ae \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ce\u03bd \u03c3\u03b5 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ae\u03c2<\/a>).    <\/p>\n<p>[\/et_pb_text][et_pb_text module_id=&#8221;trials&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h2>\u03a4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03b1\u03bd\u03bf\u03b9\u03ba\u03c4\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 &amp; \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 ECD <\/h2>\n<div class=\"tp-sticky-wrap\">\n\n<table id=\"tablepress-1\" class=\"tablepress tablepress-id-1 tablepress-responsive tablepress-responsive-stack-headers tablepress-responsive-stack-phone\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\"><strong>#<\/strong><\/th><th class=\"column-2\"><strong>NCT#<\/strong><\/th><th class=\"column-3\"><strong>Name of Study<\/strong><\/th><th class=\"column-4\"><strong>Purpose<\/strong><\/th><th class=\"column-5\"><strong>Type of Study<\/strong><\/th><th class=\"column-6\"><strong>Selection<\/strong><\/th><th class=\"column-7\"><strong>Age Requirement<\/strong><\/th><th class=\"column-8\"><strong>Care Center \/ Contact<\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">1<\/td><td class=\"column-2\"><a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05915208?id=NCT05915208&#038;draw=2&#038;rank=1\"target=\"_blank\">NCT05915208<\/a><\/td><td class=\"column-3\">Histiocytic Disorder Follow-up Study<\/td><td class=\"column-4\">To understand the health problems experienced by individuals with ECD and other histiocytic disorders.<\/td><td class=\"column-5\">Surveys only<br \/>\nObservational<br \/>\nRetrospective<\/td><td class=\"column-6\">English survey completion (online, on phone, or on paper) from the comfort of your home.<\/td><td class=\"column-7\">18 \u2013 89 years old<\/td><td class=\"column-8\">University of Alabama at Birmingham<br \/>\nBirmingham, AL  USA<br \/>\nGaurav Goyal, MD<br \/>\nhistio@uabmc.edu<br \/>\n+1-866-438-1640<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">2<\/td><td class=\"column-2\"><a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT03329274?id=NCT03329274&#038;draw=2&#038;rank=1\"target=\"_blank\">NCT03329274<\/a><\/td><td class=\"column-3\">Registry for Patients with Erdheim-Chester Disease and Other Histiocytoses<\/td><td class=\"column-4\">Determine what kinds of health problems are caused by histiocytosis, what happens as a result of different treatments, and how ECD affects people's lives, their feelings and their attitudes.<\/td><td class=\"column-5\">Surveys &amp; medical records<br \/>\nObservational<br \/>\nProspective<\/td><td class=\"column-6\">Erdheim-Chester Disease, Langerhans cell histiocytosis, Rosai Dorfman disease, or another histiocytic neoplasm<\/td><td class=\"column-7\">18 years and older<\/td><td class=\"column-8\">MSKCC<br \/>\nNew York City, NY  USA<br \/>\nEli Diamond, MD<br \/>\ndiamone1@mskcc.org<br \/>\n+1- 212-610-0243<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">3<\/td><td class=\"column-2\"><a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT03990428?id=NCT03990428&#038;draw=2&#038;rank=1\"target=\"_blank\">NCT03990428<\/a><\/td><td class=\"column-3\">Supportive Care Needs of Caregivers of People with Erdheim-Chester Disease and Other Histiocytic Diseases<\/td><td class=\"column-4\">Determine the supportive care needs of informal caregivers of people with Erdheim-Chester disease and other histiocytic diseases<\/td><td class=\"column-5\">Online surveys<br \/>\nObservational<br \/>\nProspective<\/td><td class=\"column-6\">Self id\u2019d unpaid support person for ECD, LCH, RDD, or JXG patient<\/td><td class=\"column-7\">18 years and older<\/td><td class=\"column-8\">MSKCC<br \/>\nNew York City, NY  USA<br \/>\nEli Diamond, MD<br \/>\ndiamone1@mskcc.org<br \/>\n+1- 212-610-0243<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">4<\/td><td class=\"column-2\"><a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT03017820?id=NCT03017820&#038;draw=2&#038;rank=1\"target=\"_blank\">NCT03017820<\/a><\/td><td class=\"column-3\">VSV-hIFNbeta-NIS in Treating Patients With Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma<\/td><td class=\"column-4\">Studies the best dose and side effects of recombinant vesicular stomatitis virus carrying the human NIS and IFN beta genes as a way to to kill cancer cells without damaging normal cells.  For patients whose prior treatment did not help<\/td><td class=\"column-5\">Clinical Trial<br \/>\nInterventional Treatment<\/td><td class=\"column-6\">Relapsed\/ refractory to prior ECD treatments<\/td><td class=\"column-7\">18 years and older<\/td><td class=\"column-8\">Mayo Clinic in Rochester<br \/>\nRochester, MN  USA<br \/>\nNora Bennani, MD<br \/>\nRonald Go, MD<br \/>\ngo.ronald@mayo.edu<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">5<\/td><td class=\"column-2\"><a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04640779?id=NCT04640779&#038;draw=2&#038;rank=1\"target=\"_blank\">NCT04640779<\/a><\/td><td class=\"column-3\">Low-Dose Selinexor and Choline Salicylate for Non-Hodgkin or Hodgkin Lymphoma, Histiocytic\/Dendritic Cell Neoplasm, or Relapsed or Refractory Multiple Myeloma<\/td><td class=\"column-4\">Evaluates the side effects and best dose of choline salicylate given together for patients whose prior treatment did not help.<\/td><td class=\"column-5\">Clinical Trial<br \/>\nInterventional Treatment<\/td><td class=\"column-6\">Relapsed\/ refractory to prior ECD treatments<\/td><td class=\"column-7\">18 years and older<\/td><td class=\"column-8\">Mayo Clinic in Rochester<br \/>\nRochester, MN  USA<br \/>\nJonas Paludo, M.D.   <br \/>\nRonald Go, MD<br \/>\ngo.ronald@mayo.edu<\/td>\n<\/tr>\n<tr class=\"row-7\">\n\t<td class=\"column-1\">6<\/td><td class=\"column-2\"><a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT06153173?id=NCT06153173&#038;draw=2&#038;rank=1\"target=\"_blank\">NCT06153173<\/a><\/td><td class=\"column-3\">Mirdametinib in Histiocytic Disorders<\/td><td class=\"column-4\">Determine if treatment with mirdametinib in patients with histiocytic disorders will be better than current treatments and with fewer side effects.<\/td><td class=\"column-5\">Clinical Trial<br \/>\nInterventional Treatment<\/td><td class=\"column-6\">Diagnosis of histiocytic neoplasm confirmed by a Cincinnati Children's Hospital pathologist. Exception for those with isolated pituitary\/CNS disease where biopsy is not feasible.<\/td><td class=\"column-7\">2 years and older<\/td><td class=\"column-8\">Children's Hospital Medical Center<br \/>\nCincinnati, Ohio  USA<br \/>\nMonica Trapp<br \/>\nmonica.trapp@cchmc.org<br \/>\nAshish Kumar, MD, PhD<br \/>\n+1-513-803-8574<\/td>\n<\/tr>\n<tr class=\"row-8\">\n\t<td class=\"column-1\">7<\/td><td class=\"column-2\">n\/a<\/td><td class=\"column-3\">LCH and Vitamin D<\/td><td class=\"column-4\">To investigate changes in the skeletal related quality of life (QoL) among adult LCH patients following a 3-month cholecalciferol supplementation to achieve or maintain 25(OH)D levels \u2265 30 ng\/ml (75 nmol\/L).<\/td><td class=\"column-5\">Clinical Trial<br \/>\nInterventional Adjunct Therapy<\/td><td class=\"column-6\">Histiocytosis diagnosis<\/td><td class=\"column-7\">All ages?<\/td><td class=\"column-8\">251 Hellenic Air Force &amp; VA General Hospital<br \/>\nGreece<br \/>\nMakras Polyzois, MD  <br \/>\ninfo@adultlch.gr<br \/>\n30-2107463606<\/td>\n<\/tr>\n<tr class=\"row-9\">\n\t<td class=\"column-1\">8<\/td><td class=\"column-2\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06411821?intr=ulixertinib&#038;rank=1\"target=\"_blank\">NCT06411821<\/a><\/td><td class=\"column-3\">Phase 2 Trial of Ulixertinib for Patients with Histiocytic Neoplasms<\/td><td class=\"column-4\">Clinical trial of oral ERK inhibitor<\/td><td class=\"column-5\">Clinical Trial<br \/>\nInterventional Treatment<\/td><td class=\"column-6\">Any histiocytic neoplasm<\/td><td class=\"column-7\">18 years and older<\/td><td class=\"column-8\">MSKCC<br \/>\nNYC, NY  USA<br \/>\nEli  Diamond, MD <br \/>\ndiamone1@mskcc.org<\/td>\n<\/tr>\n<tr class=\"row-10\">\n\t<td class=\"column-1\">9<\/td><td class=\"column-2\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04079179?id=NCT04079179&#038;rank=1\"target=\"_blank\">NCT04079179<\/a><\/td><td class=\"column-3\">Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders (NACHO-COBI)<\/td><td class=\"column-4\">Study of cobimetinib in children and adults with LCH and other histiocytic diorders.<\/td><td class=\"column-5\">Clinical Trial<br \/>\nInterventional Treatment<\/td><td class=\"column-6\">Relapsed\/ refractory to prior ECD treatments<\/td><td class=\"column-7\">6 months and older<\/td><td class=\"column-8\">NACHO (Baltimore, Dallas, DC, Houston, Madison, Memphis, Orange, ??)<br \/>\nTexas Children\u2019s Hospital<br \/>\nHouston, TX  USA<br \/>\nCarl Allen, MD  <br \/>\nceallen@texaschildrens.org<br \/>\n+1-832-822-4242<\/td>\n<\/tr>\n<tr class=\"row-11\">\n\t<td class=\"column-1\">10<\/td><td class=\"column-2\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05768178?term=NCT05768178&#038;rank=1\"target=\"_blank\">NCT05768178<\/a><\/td><td class=\"column-3\">Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.<\/td><td class=\"column-4\">Evaluate the efficacy of vemurafenib and cobimetinib in adult patients with rare cancers with BRAF V600 mutations.<\/td><td class=\"column-5\">Clinical Trial<br \/>\nInterventional Treatment<\/td><td class=\"column-6\">BRAF V600E<\/td><td class=\"column-7\">16 years and older<\/td><td class=\"column-8\">Multiple UK Hospitals<br \/>\nIncluding Leeds General Infirmary<br \/>\nLeeds, UK<br \/>\nMartin Elliott, MBBS<br \/>\nMartin.elliott1@nhs.net<br \/>\n0113 392 8779<\/td>\n<\/tr>\n<tr class=\"row-12\">\n\t<td class=\"column-1\">11<\/td><td class=\"column-2\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02925234?term=NCT02925234&#038;rank=1\"target=\"_blank\">NCT02925234<\/a><\/td><td class=\"column-3\">The Drug Rediscovery Protocol (DRUP Trial) (DRUP)<\/td><td class=\"column-4\">A drug-access program, in which patients are treated with registered targeted therapy matched to their molecular tumor profile.<\/td><td class=\"column-5\">Clinical Trial<br \/>\n<\/td><td class=\"column-6\">Histologically-proven disease<\/td><td class=\"column-7\">18 years and older<\/td><td class=\"column-8\">Erasmus MC<br \/>\nRotterdam, Netherlands<br \/>\nM.J.A. de Jonge, MD, PhD<br \/>\nE.E. Voest, prof.<br \/>\n0031205129111<br \/>\nDRUP@nki.nl<br \/>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_dmb_breadcrumbs _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; body_text_color=&#8221;#FFFFFF&#8221; body_font_size=&#8221;12px&#8221; link_text_color=&#8221;#35A4BB&#8221; custom_margin=&#8221;||5px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; body_font_size_tablet=&#8221;12px&#8221; body_font_size_phone=&#8221;10px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_dmb_breadcrumbs]\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2\/\u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 ECD \u03c0\u03bf\u03c5 \u03b4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 ECD. \u0391\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03b5\u03c3\u03b5\u03af\u03c2 \u03ae \u03c4\u03bf \u03b1\u03b3\u03b1\u03c0\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03b1\u03c2 [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_wds_title":"","_wds_metadesc":"","_wds_focus-keywords":"","_wds_meta-robots-adv":"","_wds_meta-robots-noindex":false,"_wds_meta-robots-nofollow":false,"_wds_meta-robots-index":false,"_wds_meta-robots-follow":false,"_wds_autolinks-exclude":false,"_wds_canonical":"","_wds_redirect":"","_wds_opengraph":[],"_wds_twitter":[],"cybocfi_hide_featured_image":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-56070","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/pages\/56070","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/comments?post=56070"}],"version-history":[{"count":0,"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/pages\/56070\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.erdheim-chester.org\/el\/wp-json\/wp\/v2\/media?parent=56070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}