{"id":53840,"date":"2015-03-14T18:21:51","date_gmt":"2015-03-14T22:21:51","guid":{"rendered":"https:\/\/www.erdheim-chester.org\/%ce%ba%ce%b1%cf%84%ce%ac%ce%b8%ce%b5%cf%83%ce%b7-%cf%80%cf%81%ce%bf%cf%83%cf%86%cf%85%ce%b3%cf%8e%ce%bd-%cf%80%ce%bb%ce%b7%cf%81%cf%89%cf%84%cf%8e%ce%bd\/"},"modified":"2025-05-07T15:50:46","modified_gmt":"2025-05-07T19:50:46","slug":"%ce%ba%ce%b1%cf%84%ce%ac%ce%b8%ce%b5%cf%83%ce%b7-%cf%80%cf%81%ce%bf%cf%83%cf%86%cf%85%ce%b3%cf%8e%ce%bd-%cf%80%ce%bb%ce%b7%cf%81%cf%89%cf%84%cf%8e%ce%bd","status":"publish","type":"page","link":"https:\/\/www.erdheim-chester.org\/el\/%ce%ba%ce%b1%cf%84%ce%ac%ce%b8%ce%b5%cf%83%ce%b7-%cf%80%cf%81%ce%bf%cf%83%cf%86%cf%85%ce%b3%cf%8e%ce%bd-%cf%80%ce%bb%ce%b7%cf%81%cf%89%cf%84%cf%8e%ce%bd\/","title":{"rendered":"\u039a\u03b1\u03c4\u03ac\u03b8\u03b5\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ce\u03bd \u03c0\u03bb\u03b7\u03c1\u03c9\u03c4\u03ce\u03bd"},"content":{"rendered":"

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\u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 ECD \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 off-label \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2, \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 ECD \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391. \u03a0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03b7 \u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b9\u03ba\u03bf\u03cd, \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03b8\u03b5\u03af \u03c0\u03b1\u03c1\u03b1\u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03b9\u03c3\u03c4\u03bf\u03bb\u03ce\u03bd \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03ac\u03c1\u03b8\u03c1\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ce\u03bd. \u039f\u03b9 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b5\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b8\u03b1 \u03c0\u03b1\u03c1\u03ac\u03c3\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03c3\u03b1\u03c2 ECD. \u0393\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b6\u03bf\u03c5\u03bd \u03b5\u03ba\u03c4\u03cc\u03c2 \u03c4\u03c9\u03bd \u0397\u03a0\u0391, \u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bf\u03b9 \u03af\u03b4\u03b9\u03b5\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2. <\/p>\n

\u0397 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c0\u03bf\u03bb\u03cd \u03c7\u03c1\u03cc\u03bd\u03bf \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1. \u03a4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 Erdheim-Chester \u0391\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c3\u03af\u03b3\u03bf\u03c5\u03c1\u03b1 \u03b5\u03be\u03b1\u03af\u03c1\u03b5\u03c3\u03b7. \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 off-label \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf ECD \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd: Anakinra, dabrafenib, trametinib, cobimetinib, cladribine \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b8\u03bf\u03c4\u03c1\u03b5\u03be\u03ac\u03c4\u03b7. \u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03c0\u03c1\u03bf\u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7, \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bb\u03cc\u03b3\u03bf\u03c5\u03c2. \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b1\u03c0\u03b1\u03bd\u03b7\u03c1\u03ac \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03bf \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bd\u03b1 \u03c4\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c8\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5. <\/p>\n

\u0397 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03ad\u03bd\u03b1\u03c2 \u03c0\u03bb\u03b7\u03c1\u03c9\u03c4\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03c5\u03c4\u03ae\u03c2 \u03ae \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03c0\u03bf\u03b9\u03cc\u03c2 \u03c4\u03bf \u03b1\u03af\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03bd\u03b5\u03b9 \u03b1\u03bd \u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA. \u038c\u03c4\u03b1\u03bd \u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b4\u03b5\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf, \u03c4\u03bf \u03b1\u03af\u03c4\u03b7\u03bc\u03b1 \u03b1\u03c0\u03bf\u03c1\u03c1\u03af\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1. \u0391\u03c5\u03c4\u03cc \u03b8\u03ad\u03c4\u03b5\u03b9 \u03c4\u03bf \u03b1\u03af\u03c4\u03b7\u03bc\u03b1 \u03c3\u03c4\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03b7\u03c2 \u03ad\u03c6\u03b5\u03c3\u03b7\u03c2, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c0\u03b7\u03b3\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03b4\u03b9\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7. \u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c4\u03b5\u03c1\u03ac\u03c3\u03c4\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf, \u03b1\u03bb\u03bb\u03ac \u03c4\u03bf \u03b1\u03af\u03c4\u03b7\u03bc\u03b1 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03af\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9. \u0395\u03ac\u03bd \u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac, \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ad\u03c2. \u038c\u03c4\u03b1\u03bd \u03b5\u03be\u03b1\u03bd\u03c4\u03bb\u03b7\u03b8\u03bf\u03cd\u03bd \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ad\u03c2, \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf \u03b4\u03b9\u03ba\u03b1\u03af\u03c9\u03bc\u03b1 \u03bd\u03b1 \u03b6\u03b7\u03c4\u03ae\u03c3\u03b5\u03b9 \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03b1\u03bd\u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03b3\u03c7\u03c9\u03c4\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03ba\u03b1\u03b9 \u03c7\u03c1\u03bf\u03bd\u03bf\u03b2\u03cc\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1\u03c4\u03c1\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b9\u03ba\u03cc. <\/p>\n

\u0393\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03c0\u03b1\u03b8\u03b5\u03b9\u03ce\u03bd, \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae \u03ac\u03c1\u03b8\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03c0\u03b9\u03c3\u03c4\u03bf\u03bb\u03ae \u03ad\u03ba\u03ba\u03bb\u03b7\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03bf\u03b3\u03c1\u03b1\u03c6\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03bd\u03c4\u03b1\u03b9. \u039f\u03b9 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03bf\u03b9 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03bc\u03bf\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03ac\u03c1\u03b8\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03bf\u03bb\u03ad\u03c2 \u03ad\u03c6\u03b5\u03c3\u03b7\u03c2 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b9\u03ba\u03cc \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03cd\u03c7\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03ad\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2. \u0386\u03bb\u03bb\u03bf\u03b9 \u03b3\u03b9\u03b1\u03c4\u03c1\u03bf\u03af \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c4\u03cd\u03c7\u03b5\u03b9 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b5\u03bd\u03c4\u03cd\u03c0\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae. \u039f\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03bf\u03bb\u03ad\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03b5\u03cd\u03bf\u03c5\u03bd \u03c9\u03c2 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2 \u03bf\u03b4\u03b7\u03b3\u03cc\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b5\u03c5\u03ba\u03cc\u03bb\u03c5\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ce\u03bd, \u03b5\u03bd\u03ce \u03c4\u03b1 \u03ac\u03c1\u03b8\u03c1\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf \u03b1\u03af\u03c4\u03b7\u03bc\u03b1 \u03bc\u03b5 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ac \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1. <\/p>\n

\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc-<\/strong>\u039f\u03b9 \u03b3\u03b9\u03b1\u03c4\u03c1\u03bf\u03af \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b9\u03ba\u03cc \u03ba\u03b1\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd \u03ba\u03c9\u03b4\u03b9\u03ba\u03cc ICD-10 D76.3 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 “\u0386\u03bb\u03bb\u03b1 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u03b9\u03c3\u03c4\u03b9\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7\u03c2” \u03ae\/\u03ba\u03b1\u03b9 C96A “\u0399\u03c3\u03c4\u03b9\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1” \u03b3\u03b9\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 (\u03b9\u03b4\u03af\u03c9\u03c2 PET Scans) \u03c3\u03b5 \u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 ECD.<\/p>\n

\u0395\u03ac\u03bd \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af\u03c4\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b2\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03ae \u03b8\u03ad\u03bb\u03b5\u03c4\u03b5 \u03bd\u03b1 \u03b4\u03ce\u03c3\u03b5\u03c4\u03b5 \u03c3\u03c7\u03cc\u03bb\u03b9\u03b1, \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7 ECDGA.<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t
Treatment<\/th>Example Appeal Letter<\/th>Supporting peer-reviewed article links\u00a0(listed according to involvement)<\/th>\n<\/tr>\n<\/thead>\n
Anakinra (Kineret)<\/td>Letter Requesting Anakinra Treatment<\/a><\/td>Bone<\/a>
\nCardiac<\/a>
\nCNS<\/a>
\nPediatric<\/a>
\nSkeletal<\/a><\/td>\n<\/tr>\n
Cladribine (Leustatin, Litak or Movectro)<\/td>Letter Requesting Cladribine Treatment<\/a><\/td>Comprehensive Review<\/a>
\nMultiple Systems<\/a>
\nOcular<\/a><\/td>\n<\/tr>\n
Methotrexate (Trexall or Rheumatrex)<\/td>Letter Requesting Methotrexate Treatment<\/a><\/td>Cardiac<\/a>
\nOcular<\/a><\/td>\n<\/tr>\n
Cobimetinib (Cotellic)<\/td>Letter Requesting Cobimetinib Treatment<\/a><\/td>Efficacy of Cobimetinib<\/a>
\nEfficacy of MEK Inhibition<\/a><\/td>\n<\/tr>\n
Trametinib (Mekinist) and\/or Dabrafenib (Tafinlar)<\/td>Letter Requesting Trametinib Treatment<\/a>
\n
\nLetter Requesting Dabrafenib Treatment<\/a><\/td>		Efficacy of Trametinib or Dabrafenib<\/a>
\nCombined Dabrafenib and Trametinib Treatment<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n

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