{"id":42584,"date":"2011-01-23T10:15:51","date_gmt":"2011-01-23T16:15:51","guid":{"rendered":"https:\/\/www.erdheim-chester.org\/?p=42584"},"modified":"2026-10-08T16:22:15","modified_gmt":"2026-10-08T21:22:15","slug":"auszeichnung-2011","status":"publish","type":"post","link":"https:\/\/www.erdheim-chester.org\/de\/2011-award\/","title":{"rendered":"Hypoxie und Entz\u00fcndung in der Mikroumgebung bei der Erdheim-Chester-Krankheit: Erkenntnisse zur Pathogenese und Implikationen f\u00fcr Therapieans\u00e4tze"},"content":{"rendered":"<h3>[et_pb_section global_module=\"175201\"][\/et_pb_section]<\/h3>\n<h4><strong>Year Awarded:<\/strong> 2011<br \/>\n<strong>Amount: <\/strong>49,745 USD<\/h4>\n<p>In April 2010, only one month after receiving a 501(c)(3) designation, the organization announced it would be awarding a $50,000 ECD research grant and put out a Request for Proposals (RFP) to the international medical research community.\u00a0 In November 2010, the first grant recipient was chosen.<\/p>\n<p>The ECD Global Alliance 2010 grant was awarded to Lorenzo Dagna, MD at San Raffaele Scientific Institute in Milano, Italy for the study described as, \u201c<a href=\"https:\/\/www.erdheim-chester.org\/DataFiles\/PresentationsAndArticles\/Dagna_2010_Study_Abstract.pdf\" target=\"_blank\" rel=\"noopener\">Hypoxia and inflammation in Erdheim-Chester disease microenvironment: insights on the pathogenesis and implications for therapy proposal\u201d<\/a>. The aim of this study was to better define the microenvironment inside ECD lesions and to evaluate the possibility of using specific drugs, already available for human usage, to find new therapeutic options for the disease.\u202f The study ran from January 2011 until June 2012.\u202f The results of this study can be found in the Journal of Clinical Oncology, Vol. 310, 2012, in an article entitled, \u201c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22869874\/\" target=\"_blank\" rel=\"noopener\" aria-label=\"Tumor Necrosis Factor as a Master Regulator of Inflammation in Erdheim-Chester Disease: Rationale for the Treatment of Patients with Infliximab - opens in new tab - opens in new tab\">Tumor Necrosis Factor as a Master Regulator of Inflammation in Erdheim-Chester Disease: Rationale for the Treatment of Patients with Infliximab<\/a>.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ECD Global Alliance awards a $49,745 research grant to Lorenzo Dagna at San Raffaele Scientific Institute in Milano, Italy. The study investigated the microenvironment of ECD lesions, revealing Tumor Necrosis Factor as a key inflammation regulator and exploring potential therapeutic options.<\/p>","protected":false},"author":20,"featured_media":92321,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","cybocfi_hide_featured_image":"","wds_primary_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[306],"tags":[325],"class_list":["post-42584","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-past-awards","tag-325"],"_links":{"self":[{"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/posts\/42584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/comments?post=42584"}],"version-history":[{"count":1,"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/posts\/42584\/revisions"}],"predecessor-version":[{"id":175204,"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/posts\/42584\/revisions\/175204"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/media\/92321"}],"wp:attachment":[{"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/media?parent=42584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/categories?post=42584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.erdheim-chester.org\/de\/wp-json\/wp\/v2\/tags?post=42584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}